node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
UU083 | gyrA | UU083 | UU082 | Conserved hypothetical; Belongs to the CinA family. | DNA topoisomerase chain A - DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an [...] | 0.548 |
UU083 | recA | UU083 | UU084 | Conserved hypothetical; Belongs to the CinA family. | Recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.810 |
UU083 | rny | UU083 | UU085 | Conserved hypothetical; Belongs to the CinA family. | Conserved hypothetical; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. | 0.613 |
deaD | rnpA | UU582 | UU603 | ATP-dependent RNA helicase. | Ribonuclease p - protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.463 |
deaD | rny | UU582 | UU085 | ATP-dependent RNA helicase. | Conserved hypothetical; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. | 0.476 |
gyrA | UU083 | UU082 | UU083 | DNA topoisomerase chain A - DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an [...] | Conserved hypothetical; Belongs to the CinA family. | 0.548 |
gyrA | recA | UU082 | UU084 | DNA topoisomerase chain A - DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an [...] | Recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.748 |
gyrA | rny | UU082 | UU085 | DNA topoisomerase chain A - DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an [...] | Conserved hypothetical; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. | 0.412 |
hisT | rny | UU536 | UU085 | Pseudouridylate synthase I; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | Conserved hypothetical; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. | 0.747 |
hisT | thiI | UU536 | UU418 | Pseudouridylate synthase I; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | Thiamin biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.767 |
pfkA | rny | UU185 | UU085 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. | Conserved hypothetical; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. | 0.504 |
recA | UU083 | UU084 | UU083 | Recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Conserved hypothetical; Belongs to the CinA family. | 0.810 |
recA | gyrA | UU084 | UU082 | Recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | DNA topoisomerase chain A - DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an [...] | 0.748 |
recA | rny | UU084 | UU085 | Recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Conserved hypothetical; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. | 0.701 |
rnpA | deaD | UU603 | UU582 | Ribonuclease p - protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | ATP-dependent RNA helicase. | 0.463 |
rnpA | rny | UU603 | UU085 | Ribonuclease p - protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | Conserved hypothetical; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. | 0.499 |
rny | UU083 | UU085 | UU083 | Conserved hypothetical; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. | Conserved hypothetical; Belongs to the CinA family. | 0.613 |
rny | deaD | UU085 | UU582 | Conserved hypothetical; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. | ATP-dependent RNA helicase. | 0.476 |
rny | gyrA | UU085 | UU082 | Conserved hypothetical; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. | DNA topoisomerase chain A - DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an [...] | 0.412 |
rny | hisT | UU085 | UU536 | Conserved hypothetical; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. | Pseudouridylate synthase I; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.747 |