node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GLYA3 | WS0081 | WS0085 | WS0081 | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Conserved hypothetical protein; Belongs to the UPF0234 family. | 0.533 |
GLYA3 | WS0083 | WS0085 | WS0083 | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | PUTATIVE INTEGRAL MEMBRANE PROTEIN. | 0.780 |
GLYA3 | WS0086 | WS0085 | WS0086 | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | HYPOTHETICAL 21.5 KDA PROTEIN. | 0.758 |
GLYA3 | cute | WS0085 | WS0080 | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | APOLIPOPROTEIN N-ACYLTRANSFERASE; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. | 0.598 |
GLYA3 | lysS | WS0085 | WS0084 | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | LYSYL-TRNA SYNTHETASE; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.900 |
LSPA | bamD | WS0819 | WS1973 | LIPOPROTEIN SIGNAL PEPTIDASE A; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | Conserved hypothetical protein-TPR repeat containing protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.738 |
LSPA | cute | WS0819 | WS0080 | LIPOPROTEIN SIGNAL PEPTIDASE A; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | APOLIPOPROTEIN N-ACYLTRANSFERASE; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. | 0.789 |
WS0081 | GLYA3 | WS0081 | WS0085 | Conserved hypothetical protein; Belongs to the UPF0234 family. | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.533 |
WS0081 | WS0083 | WS0081 | WS0083 | Conserved hypothetical protein; Belongs to the UPF0234 family. | PUTATIVE INTEGRAL MEMBRANE PROTEIN. | 0.574 |
WS0081 | WS0086 | WS0081 | WS0086 | Conserved hypothetical protein; Belongs to the UPF0234 family. | HYPOTHETICAL 21.5 KDA PROTEIN. | 0.461 |
WS0081 | cute | WS0081 | WS0080 | Conserved hypothetical protein; Belongs to the UPF0234 family. | APOLIPOPROTEIN N-ACYLTRANSFERASE; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. | 0.802 |
WS0081 | lysS | WS0081 | WS0084 | Conserved hypothetical protein; Belongs to the UPF0234 family. | LYSYL-TRNA SYNTHETASE; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.533 |
WS0083 | GLYA3 | WS0083 | WS0085 | PUTATIVE INTEGRAL MEMBRANE PROTEIN. | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.780 |
WS0083 | WS0081 | WS0083 | WS0081 | PUTATIVE INTEGRAL MEMBRANE PROTEIN. | Conserved hypothetical protein; Belongs to the UPF0234 family. | 0.574 |
WS0083 | WS0086 | WS0083 | WS0086 | PUTATIVE INTEGRAL MEMBRANE PROTEIN. | HYPOTHETICAL 21.5 KDA PROTEIN. | 0.654 |
WS0083 | WS0233 | WS0083 | WS0233 | PUTATIVE INTEGRAL MEMBRANE PROTEIN. | Conserved hypothetical protein. | 0.524 |
WS0083 | bamD | WS0083 | WS1973 | PUTATIVE INTEGRAL MEMBRANE PROTEIN. | Conserved hypothetical protein-TPR repeat containing protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.548 |
WS0083 | cute | WS0083 | WS0080 | PUTATIVE INTEGRAL MEMBRANE PROTEIN. | APOLIPOPROTEIN N-ACYLTRANSFERASE; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. | 0.641 |
WS0083 | lysS | WS0083 | WS0084 | PUTATIVE INTEGRAL MEMBRANE PROTEIN. | LYSYL-TRNA SYNTHETASE; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.752 |
WS0086 | GLYA3 | WS0086 | WS0085 | HYPOTHETICAL 21.5 KDA PROTEIN. | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.758 |