node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GLYA3 | ILVA | WS0085 | WS0132 | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | THREONINE DEHYDRATASE BIOSYNTHETIC. | 0.933 |
GLYA3 | PSSA | WS0085 | WS0623 | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | PHOSPHATIDYLTRANSFERASE; CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
GLYA3 | SERB | WS0085 | WS2081 | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | PUTATIVE PHOSPHOSERINE PHOSPHATASE. | 0.942 |
GLYA3 | TRPA | WS0085 | WS1827 | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | TRYPTOPHAN SYNTHASE ALPHA CHAIN; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.931 |
GLYA3 | trpB | WS0085 | WS0719 | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | PUTATIVE TRYPTOPHAN SYNTHASE; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.910 |
GLYA3 | trpB2 | WS0085 | WS1351 | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | TRYPTOPHAN SYNTHASE BETA CHAIN; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.910 |
ILVA | GLYA3 | WS0132 | WS0085 | THREONINE DEHYDRATASE BIOSYNTHETIC. | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.933 |
ILVA | PSSA | WS0132 | WS0623 | THREONINE DEHYDRATASE BIOSYNTHETIC. | PHOSPHATIDYLTRANSFERASE; CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
ILVA | SERB | WS0132 | WS2081 | THREONINE DEHYDRATASE BIOSYNTHETIC. | PUTATIVE PHOSPHOSERINE PHOSPHATASE. | 0.913 |
ILVA | TRPA | WS0132 | WS1827 | THREONINE DEHYDRATASE BIOSYNTHETIC. | TRYPTOPHAN SYNTHASE ALPHA CHAIN; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.922 |
ILVA | TRPC | WS0132 | WS1912 | THREONINE DEHYDRATASE BIOSYNTHETIC. | INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE; Belongs to the TrpC family. | 0.405 |
ILVA | trpB | WS0132 | WS0719 | THREONINE DEHYDRATASE BIOSYNTHETIC. | PUTATIVE TRYPTOPHAN SYNTHASE; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.926 |
ILVA | trpB2 | WS0132 | WS1351 | THREONINE DEHYDRATASE BIOSYNTHETIC. | TRYPTOPHAN SYNTHASE BETA CHAIN; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.926 |
PSSA | GLYA3 | WS0623 | WS0085 | PHOSPHATIDYLTRANSFERASE; CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.900 |
PSSA | ILVA | WS0623 | WS0132 | PHOSPHATIDYLTRANSFERASE; CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | THREONINE DEHYDRATASE BIOSYNTHETIC. | 0.900 |
PSSA | SERB | WS0623 | WS2081 | PHOSPHATIDYLTRANSFERASE; CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | PUTATIVE PHOSPHOSERINE PHOSPHATASE. | 0.906 |
PSSA | TRPA | WS0623 | WS1827 | PHOSPHATIDYLTRANSFERASE; CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | TRYPTOPHAN SYNTHASE ALPHA CHAIN; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.900 |
PSSA | trpB | WS0623 | WS0719 | PHOSPHATIDYLTRANSFERASE; CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | PUTATIVE TRYPTOPHAN SYNTHASE; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
PSSA | trpB2 | WS0623 | WS1351 | PHOSPHATIDYLTRANSFERASE; CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | TRYPTOPHAN SYNTHASE BETA CHAIN; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
SERB | GLYA3 | WS2081 | WS0085 | PUTATIVE PHOSPHOSERINE PHOSPHATASE. | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.942 |