node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PEPE_1130 | PEPE_1372 | PEPE_1130 | PEPE_1372 | Exonuclease RecJ. | ATP-dependent DNA helicase PcrA. | 0.495 |
PEPE_1130 | murC | PEPE_1130 | PEPE_0686 | Exonuclease RecJ. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.449 |
PEPE_1130 | mutL | PEPE_1130 | PEPE_1273 | Exonuclease RecJ. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.744 |
PEPE_1130 | obg | PEPE_1130 | PEPE_1134 | Exonuclease RecJ. | Predicted GTPase; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.468 |
PEPE_1130 | polA | PEPE_1130 | PEPE_0688 | Exonuclease RecJ. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.702 |
PEPE_1130 | recA | PEPE_1130 | PEPE_1276 | Exonuclease RecJ. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.604 |
PEPE_1130 | uvrA | PEPE_1130 | PEPE_0449 | Exonuclease RecJ. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.466 |
PEPE_1130 | uvrB | PEPE_1130 | PEPE_0448 | Exonuclease RecJ. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.425 |
PEPE_1130 | uvrC | PEPE_1130 | PEPE_1135 | Exonuclease RecJ. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.653 |
PEPE_1137 | obg | PEPE_1137 | PEPE_1134 | Arginine/lysine/histidine transporter system substrate-binding protein; TC 3.A.1.3.-; TC 3.A.1.3.-. | Predicted GTPase; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.439 |
PEPE_1137 | polA | PEPE_1137 | PEPE_0688 | Arginine/lysine/histidine transporter system substrate-binding protein; TC 3.A.1.3.-; TC 3.A.1.3.-. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.400 |
PEPE_1137 | uvrC | PEPE_1137 | PEPE_1135 | Arginine/lysine/histidine transporter system substrate-binding protein; TC 3.A.1.3.-; TC 3.A.1.3.-. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.709 |
PEPE_1372 | PEPE_1130 | PEPE_1372 | PEPE_1130 | ATP-dependent DNA helicase PcrA. | Exonuclease RecJ. | 0.495 |
PEPE_1372 | mutL | PEPE_1372 | PEPE_1273 | ATP-dependent DNA helicase PcrA. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.767 |
PEPE_1372 | polA | PEPE_1372 | PEPE_0688 | ATP-dependent DNA helicase PcrA. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.883 |
PEPE_1372 | recA | PEPE_1372 | PEPE_1276 | ATP-dependent DNA helicase PcrA. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.889 |
PEPE_1372 | uvrA | PEPE_1372 | PEPE_0449 | ATP-dependent DNA helicase PcrA. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.696 |
PEPE_1372 | uvrB | PEPE_1372 | PEPE_0448 | ATP-dependent DNA helicase PcrA. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.868 |
PEPE_1372 | uvrC | PEPE_1372 | PEPE_1135 | ATP-dependent DNA helicase PcrA. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.691 |
murC | PEPE_1130 | PEPE_0686 | PEPE_1130 | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | Exonuclease RecJ. | 0.449 |