node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acoL | bfmBC | BL03015 | BL01503 | Acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase). | 0.599 |
acoL | gcvH | BL03015 | BL02176 | Acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.924 |
acoL | gcvPA | BL03015 | BL01561 | Acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Glycine decarboxylase (subunit 1) (glycine cleavage system protein P); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.879 |
acoL | gcvPB | BL03015 | BL01560 | Acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Glycine decarboxylase (subunit 2) (glycine cleavage system protein P); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.779 |
acoL | gcvT | BL03015 | BL01562 | Acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Aminomethyltransferase (glycine cleavage system protein T); The glycine cleavage system catalyzes the degradation of glycine. | 0.899 |
acoL | glnA | BL03015 | BL03233 | Acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Glutamine synthetase. | 0.624 |
acoL | gltA | BL03015 | BL01971 | Acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Glutamate synthase (large subunit). | 0.842 |
acoL | glyA | BL03015 | BL03991 | Acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.691 |
acoL | pdhD | BL03015 | BL01619 | Acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes. | 0.794 |
acoL | purQ | BL03015 | BL01481 | Acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Phosphoribosylformylglycinamidine synthetase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.548 |
bfmBC | acoL | BL01503 | BL03015 | Branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase). | Acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | 0.599 |
bfmBC | gcvH | BL01503 | BL02176 | Branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase). | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.921 |
bfmBC | gcvPA | BL01503 | BL01561 | Branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase). | Glycine decarboxylase (subunit 1) (glycine cleavage system protein P); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.883 |
bfmBC | gcvPB | BL01503 | BL01560 | Branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase). | Glycine decarboxylase (subunit 2) (glycine cleavage system protein P); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.789 |
bfmBC | gcvT | BL01503 | BL01562 | Branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase). | Aminomethyltransferase (glycine cleavage system protein T); The glycine cleavage system catalyzes the degradation of glycine. | 0.908 |
bfmBC | glnA | BL01503 | BL03233 | Branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase). | Glutamine synthetase. | 0.624 |
bfmBC | gltA | BL01503 | BL01971 | Branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase). | Glutamate synthase (large subunit). | 0.842 |
bfmBC | glyA | BL01503 | BL03991 | Branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.679 |
bfmBC | pdhD | BL01503 | BL01619 | Branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase). | Dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes. | 0.787 |
bfmBC | purQ | BL01503 | BL01481 | Branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase). | Phosphoribosylformylglycinamidine synthetase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.548 |