node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Saro_1100 | Saro_2261 | Saro_1100 | Saro_2261 | L-threonine ammonia-lyase. | Acetolactate synthase, large subunit. | 0.932 |
Saro_1100 | Saro_2671 | Saro_1100 | Saro_2671 | L-threonine ammonia-lyase. | Branched chain amino acid aminotransferase apoenzyme. | 0.911 |
Saro_1100 | ilvC | Saro_1100 | Saro_2263 | L-threonine ammonia-lyase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.718 |
Saro_1100 | ilvD | Saro_1100 | Saro_1784 | L-threonine ammonia-lyase. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.879 |
Saro_1100 | leuC | Saro_1100 | Saro_1170 | L-threonine ammonia-lyase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.560 |
Saro_1785 | Saro_1787 | Saro_1785 | Saro_1787 | Hypothetical protein. | 23S rRNA m(5)U-1939 methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | 0.834 |
Saro_1785 | ilvD | Saro_1785 | Saro_1784 | Hypothetical protein. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.834 |
Saro_1785 | nnrE | Saro_1785 | Saro_1786 | Hypothetical protein. | YjeF-related protein-like protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repai [...] | 0.843 |
Saro_1787 | Saro_1785 | Saro_1787 | Saro_1785 | 23S rRNA m(5)U-1939 methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | Hypothetical protein. | 0.834 |
Saro_1787 | ilvD | Saro_1787 | Saro_1784 | 23S rRNA m(5)U-1939 methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.852 |
Saro_1787 | nnrE | Saro_1787 | Saro_1786 | 23S rRNA m(5)U-1939 methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | YjeF-related protein-like protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repai [...] | 0.847 |
Saro_2261 | Saro_1100 | Saro_2261 | Saro_1100 | Acetolactate synthase, large subunit. | L-threonine ammonia-lyase. | 0.932 |
Saro_2261 | Saro_2671 | Saro_2261 | Saro_2671 | Acetolactate synthase, large subunit. | Branched chain amino acid aminotransferase apoenzyme. | 0.455 |
Saro_2261 | ilvC | Saro_2261 | Saro_2263 | Acetolactate synthase, large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.993 |
Saro_2261 | ilvD | Saro_2261 | Saro_1784 | Acetolactate synthase, large subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.900 |
Saro_2261 | leuA | Saro_2261 | Saro_2267 | Acetolactate synthase, large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.876 |
Saro_2261 | leuC | Saro_2261 | Saro_1170 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.621 |
Saro_2671 | Saro_1100 | Saro_2671 | Saro_1100 | Branched chain amino acid aminotransferase apoenzyme. | L-threonine ammonia-lyase. | 0.911 |
Saro_2671 | Saro_2261 | Saro_2671 | Saro_2261 | Branched chain amino acid aminotransferase apoenzyme. | Acetolactate synthase, large subunit. | 0.455 |
Saro_2671 | ilvC | Saro_2671 | Saro_2263 | Branched chain amino acid aminotransferase apoenzyme. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.551 |