node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Saro_0732 | Saro_0733 | Saro_0732 | Saro_0733 | Formate dehydrogenase gamma subunit. | Formate dehydrogenase beta subunit. | 0.999 |
Saro_0732 | Saro_0735 | Saro_0732 | Saro_0735 | Formate dehydrogenase gamma subunit. | Formate dehydrogenase alpha subunit. | 0.997 |
Saro_0732 | purU | Saro_0732 | Saro_2862 | Formate dehydrogenase gamma subunit. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.901 |
Saro_0733 | Saro_0732 | Saro_0733 | Saro_0732 | Formate dehydrogenase beta subunit. | Formate dehydrogenase gamma subunit. | 0.999 |
Saro_0733 | Saro_0735 | Saro_0733 | Saro_0735 | Formate dehydrogenase beta subunit. | Formate dehydrogenase alpha subunit. | 0.997 |
Saro_0733 | purU | Saro_0733 | Saro_2862 | Formate dehydrogenase beta subunit. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.900 |
Saro_0735 | Saro_0732 | Saro_0735 | Saro_0732 | Formate dehydrogenase alpha subunit. | Formate dehydrogenase gamma subunit. | 0.997 |
Saro_0735 | Saro_0733 | Saro_0735 | Saro_0733 | Formate dehydrogenase alpha subunit. | Formate dehydrogenase beta subunit. | 0.997 |
Saro_0735 | purU | Saro_0735 | Saro_2862 | Formate dehydrogenase alpha subunit. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.900 |
Saro_1850 | Saro_3206 | Saro_1850 | Saro_3206 | Aminomethyltransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.910 |
Saro_1850 | Saro_3207 | Saro_1850 | Saro_3207 | Aminomethyltransferase. | Methionine synthase (B12-dependent). | 0.919 |
Saro_1850 | Saro_3262 | Saro_1850 | Saro_3262 | Aminomethyltransferase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.910 |
Saro_1850 | folD | Saro_1850 | Saro_3300 | Aminomethyltransferase. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.947 |
Saro_1850 | glyA | Saro_1850 | Saro_2240 | Aminomethyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.995 |
Saro_1850 | purN | Saro_1850 | Saro_0898 | Aminomethyltransferase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.920 |
Saro_1850 | purU | Saro_1850 | Saro_2862 | Aminomethyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.911 |
Saro_3206 | Saro_1850 | Saro_3206 | Saro_1850 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase. | 0.910 |
Saro_3206 | Saro_3207 | Saro_3206 | Saro_3207 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase (B12-dependent). | 0.999 |
Saro_3206 | Saro_3262 | Saro_3206 | Saro_3262 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.900 |
Saro_3206 | glyA | Saro_3206 | Saro_2240 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.930 |