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ddlA protein (Staphylococcus haemolyticus) - STRING interaction network
"ddlA" - D-alanine--D-alanine ligase in Staphylococcus haemolyticus
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ddlAD-alanine--D-alanine ligase; Cell wall formation (356 aa)    
Predicted Functional Partners:
murF
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily (451 aa)
 
  0.997
alr1
Alanine racemase; Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids; Belongs to the alanine racemase family (382 aa)
 
   
  0.980
murC
UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family (437 aa)
 
  0.975
alr2
Alanine racemase; Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids; Belongs to the alanine racemase family (358 aa)
 
   
  0.936
dltA
D-alanine--D-alanyl carrier protein ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall; Belongs to the AT [...] (485 aa)
       
  0.922
dat
D-alanine aminotransferase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction (282 aa)
       
  0.918
dltC
D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall (78 aa)
         
  0.906
murB
UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation (307 aa)
 
   
  0.894
purK
N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family (378 aa)
   
   
  0.843
murD
UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA); Belongs to the MurCDEF family (449 aa)
   
  0.814
Your Current Organism:
Staphylococcus haemolyticus
NCBI taxonomy Id: 279808
Other names: S. haemolyticus JCSC1435, Staphylococcus haemolyticus, Staphylococcus haemolyticus JCSC1435, Staphylococcus haemolyticus str. JCSC1435, Staphylococcus haemolyticus strain JCSC1435
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