node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
clpB | clpP | Lxx23630 | Lxx07850 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.825 |
clpB | dnaJ | Lxx23630 | Lxx14640 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.741 |
clpB | dnaJ-2 | Lxx23630 | Lxx23760 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | DnaJ protein; Identified by sequence similarity. | 0.741 |
clpB | dnaK | Lxx23630 | Lxx23780 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | DnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.957 |
clpB | groEL | Lxx23630 | Lxx18010 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | 60kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.626 |
clpB | groES | Lxx23630 | Lxx19880 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | 10kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.694 |
clpB | grpE | Lxx23630 | Lxx23770 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.856 |
clpB | hrcA | Lxx23630 | Lxx14650 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | Transcriptional regulator, HrcA family; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.639 |
clpB | hspR | Lxx23630 | Lxx23750 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | Heat shock protein; Identified by sequence similarity. | 0.471 |
clpC | clpP | Lxx21340 | Lxx07850 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.825 |
clpC | dnaJ | Lxx21340 | Lxx14640 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.791 |
clpC | dnaJ-2 | Lxx21340 | Lxx23760 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | DnaJ protein; Identified by sequence similarity. | 0.791 |
clpC | dnaK | Lxx21340 | Lxx23780 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | DnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.957 |
clpC | groEL | Lxx21340 | Lxx18010 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | 60kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.626 |
clpC | groES | Lxx21340 | Lxx19880 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | 10kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.694 |
clpC | grpE | Lxx21340 | Lxx23770 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.856 |
clpC | hrcA | Lxx21340 | Lxx14650 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | Transcriptional regulator, HrcA family; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.615 |
clpC | hspR | Lxx21340 | Lxx23750 | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | Heat shock protein; Identified by sequence similarity. | 0.471 |
clpP | clpB | Lxx07850 | Lxx23630 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | 0.825 |
clpP | clpC | Lxx07850 | Lxx21340 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease, ATP-binding subunit; Identified by sequence similarity; Belongs to the ClpA/ClpB family. | 0.825 |