STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIX3SIX homeobox 3. (336 aa)    
Predicted Functional Partners:
ALX1
ALX homeobox 1.
      
 0.799
EDAR
Ectodysplasin A receptor.
      
 0.775
CCNB1
Cyclin B1; Belongs to the cyclin family.
      
 0.688
VAX2
Ventral anterior homeobox 2.
   
 
 0.641
PAX6
Paired box 6.
   
 
 0.603
OTX2
Orthodenticle homeobox 2.
   
 
 0.576
VSX2
Visual system homeobox 2.
   
  
 0.559
ISL1
ISL LIM homeobox 1.
   
  
 0.530
OTP
Orthopedia homeobox.
      
 0.522
SHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
      
 0.521
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.