node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APLF | LIG1 | ENSACAP00000018834 | ENSACAP00000011038 | Aprataxin and PNKP like factor. | DNA ligase. | 0.533 |
APLF | LIG4 | ENSACAP00000018834 | ENSACAP00000014275 | Aprataxin and PNKP like factor. | DNA ligase. | 0.767 |
APLF | PARP1 | ENSACAP00000018834 | ENSACAP00000006218 | Aprataxin and PNKP like factor. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.749 |
APLF | PNKP | ENSACAP00000018834 | ENSACAP00000012550 | Aprataxin and PNKP like factor. | Polynucleotide kinase 3'-phosphatase. | 0.561 |
APLF | POLB | ENSACAP00000018834 | ENSACAP00000002030 | Aprataxin and PNKP like factor. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.711 |
APLF | POLL | ENSACAP00000018834 | ENSACAP00000011615 | Aprataxin and PNKP like factor. | DNA polymerase lambda; Belongs to the DNA polymerase type-X family. | 0.481 |
APLF | REC114 | ENSACAP00000018834 | ENSACAP00000020329 | Aprataxin and PNKP like factor. | REC114 meiotic recombination protein. | 0.426 |
APLF | XRCC6 | ENSACAP00000018834 | ENSACAP00000004463 | Aprataxin and PNKP like factor. | X-ray repair cross complementing 6. | 0.936 |
APLF | xrcc1 | ENSACAP00000018834 | ENSACAP00000004173 | Aprataxin and PNKP like factor. | Uncharacterized protein. | 0.902 |
FEN1 | LIG1 | ENSACAP00000019151 | ENSACAP00000011038 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA ligase. | 0.995 |
FEN1 | LIG4 | ENSACAP00000019151 | ENSACAP00000014275 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA ligase. | 0.861 |
FEN1 | PARP1 | ENSACAP00000019151 | ENSACAP00000006218 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.778 |
FEN1 | PNKP | ENSACAP00000019151 | ENSACAP00000012550 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Polynucleotide kinase 3'-phosphatase. | 0.630 |
FEN1 | POLB | ENSACAP00000019151 | ENSACAP00000002030 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.875 |
FEN1 | POLL | ENSACAP00000019151 | ENSACAP00000011615 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase lambda; Belongs to the DNA polymerase type-X family. | 0.783 |
FEN1 | XRCC6 | ENSACAP00000019151 | ENSACAP00000004463 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | X-ray repair cross complementing 6. | 0.794 |
FEN1 | xrcc1 | ENSACAP00000019151 | ENSACAP00000004173 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.885 |
LIG1 | APLF | ENSACAP00000011038 | ENSACAP00000018834 | DNA ligase. | Aprataxin and PNKP like factor. | 0.533 |
LIG1 | FEN1 | ENSACAP00000011038 | ENSACAP00000019151 | DNA ligase. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.995 |
LIG1 | LIG4 | ENSACAP00000011038 | ENSACAP00000014275 | DNA ligase. | DNA ligase. | 0.591 |