node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERCC4 | FANCM | ENSACAP00000003517 | ENSACAP00000004068 | ERCC excision repair 4, endonuclease catalytic subunit. | FA complementation group M. | 0.784 |
ERCC4 | MEIOB | ENSACAP00000003517 | ENSACAP00000006034 | ERCC excision repair 4, endonuclease catalytic subunit. | Meiosis specific with OB-fold. | 0.873 |
ERCC4 | RFWD3 | ENSACAP00000003517 | ENSACAP00000006486 | ERCC excision repair 4, endonuclease catalytic subunit. | Ring finger and WD repeat domain 3. | 0.540 |
ERCC4 | RPA1 | ENSACAP00000003517 | ENSACAP00000014346 | ERCC excision repair 4, endonuclease catalytic subunit. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.947 |
ERCC4 | RPA3 | ENSACAP00000003517 | ENSACAP00000012819 | ERCC excision repair 4, endonuclease catalytic subunit. | Replication protein A3. | 0.697 |
ERCC4 | SMARCAL1 | ENSACAP00000003517 | ENSACAP00000004543 | ERCC excision repair 4, endonuclease catalytic subunit. | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. | 0.443 |
ERCC4 | WRN | ENSACAP00000003517 | ENSACAP00000003095 | ERCC excision repair 4, endonuclease catalytic subunit. | WRN RecQ like helicase. | 0.991 |
FANCM | ERCC4 | ENSACAP00000004068 | ENSACAP00000003517 | FA complementation group M. | ERCC excision repair 4, endonuclease catalytic subunit. | 0.784 |
FANCM | MEIOB | ENSACAP00000004068 | ENSACAP00000006034 | FA complementation group M. | Meiosis specific with OB-fold. | 0.999 |
FANCM | RFWD3 | ENSACAP00000004068 | ENSACAP00000006486 | FA complementation group M. | Ring finger and WD repeat domain 3. | 0.560 |
FANCM | RPA1 | ENSACAP00000004068 | ENSACAP00000014346 | FA complementation group M. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.999 |
FANCM | RPA3 | ENSACAP00000004068 | ENSACAP00000012819 | FA complementation group M. | Replication protein A3. | 0.971 |
FANCM | SMARCAL1 | ENSACAP00000004068 | ENSACAP00000004543 | FA complementation group M. | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. | 0.774 |
FANCM | TIPIN | ENSACAP00000004068 | ENSACAP00000004150 | FA complementation group M. | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. | 0.515 |
FANCM | WRN | ENSACAP00000004068 | ENSACAP00000003095 | FA complementation group M. | WRN RecQ like helicase. | 0.999 |
HMCES | RFWD3 | ENSACAP00000005896 | ENSACAP00000006486 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | Ring finger and WD repeat domain 3. | 0.558 |
HMCES | SMARCAL1 | ENSACAP00000005896 | ENSACAP00000004543 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. | 0.511 |
HMCES | TIPIN | ENSACAP00000005896 | ENSACAP00000004150 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. | 0.517 |
MEIOB | ERCC4 | ENSACAP00000006034 | ENSACAP00000003517 | Meiosis specific with OB-fold. | ERCC excision repair 4, endonuclease catalytic subunit. | 0.873 |
MEIOB | FANCM | ENSACAP00000006034 | ENSACAP00000004068 | Meiosis specific with OB-fold. | FA complementation group M. | 0.999 |