node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DMC1 | FANCM | ENSACAP00000007974 | ENSACAP00000004068 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | FA complementation group M. | 0.924 |
DMC1 | RAD51 | ENSACAP00000007974 | ENSACAP00000013598 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.971 |
DMC1 | RAD51B | ENSACAP00000007974 | ENSACAP00000005463 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | RAD51 paralog B. | 0.937 |
DMC1 | RAD52 | ENSACAP00000007974 | ENSACAP00000000025 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | RAD52 homolog, DNA repair protein. | 0.866 |
DMC1 | TOP3A | ENSACAP00000007974 | ENSACAP00000009102 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.918 |
DMC1 | TOP3B | ENSACAP00000007974 | ENSACAP00000001569 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.856 |
DMC1 | WRN | ENSACAP00000007974 | ENSACAP00000003095 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | WRN RecQ like helicase. | 0.991 |
DMC1 | XRCC2 | ENSACAP00000007974 | ENSACAP00000010421 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | X-ray repair cross complementing 2. | 0.877 |
DMC1 | XRCC3 | ENSACAP00000007974 | ENSACAP00000010557 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. | 0.970 |
DMC1 | brca2 | ENSACAP00000007974 | ENSACAP00000004459 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | Tower domain-containing protein. | 0.924 |
FANCM | DMC1 | ENSACAP00000004068 | ENSACAP00000007974 | FA complementation group M. | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | 0.924 |
FANCM | RAD51 | ENSACAP00000004068 | ENSACAP00000013598 | FA complementation group M. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.981 |
FANCM | RAD51B | ENSACAP00000004068 | ENSACAP00000005463 | FA complementation group M. | RAD51 paralog B. | 0.981 |
FANCM | RAD52 | ENSACAP00000004068 | ENSACAP00000000025 | FA complementation group M. | RAD52 homolog, DNA repair protein. | 0.997 |
FANCM | TOP3A | ENSACAP00000004068 | ENSACAP00000009102 | FA complementation group M. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.998 |
FANCM | TOP3B | ENSACAP00000004068 | ENSACAP00000001569 | FA complementation group M. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.998 |
FANCM | WRN | ENSACAP00000004068 | ENSACAP00000003095 | FA complementation group M. | WRN RecQ like helicase. | 0.999 |
FANCM | XRCC2 | ENSACAP00000004068 | ENSACAP00000010421 | FA complementation group M. | X-ray repair cross complementing 2. | 0.818 |
FANCM | XRCC3 | ENSACAP00000004068 | ENSACAP00000010557 | FA complementation group M. | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. | 0.924 |
FANCM | brca2 | ENSACAP00000004068 | ENSACAP00000004459 | FA complementation group M. | Tower domain-containing protein. | 0.791 |