STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APPAmyloid beta precursor protein. (776 aa)    
Predicted Functional Partners:
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 
 0.968
H9G3K0_ANOCA
PID domain-containing protein.
   
 
 0.963
sorl1
Uncharacterized protein.
    
 0.955
APBA1
Amyloid beta precursor protein binding family A member 1.
   
 
 0.951
TNFRSF21
TNF receptor superfamily member 21.
    
 
 0.934
PITRM1
Pitrilysin metallopeptidase 1.
    
 
 0.899
LOC100555750
Uncharacterized protein; Belongs to the prion family.
   
 0.892
PSEN2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 
 0.883
ncstn
Ncstrn_small domain-containing protein.
    
 0.846
H9GQ91_ANOCA
Uncharacterized protein.
    
 0.846
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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