node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL1984 | mutY | IL1984 | IL1983 | Uncharacterized conserved protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. | A/G-specific DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.864 |
IL1984 | oprF | IL1984 | IL1982 | Uncharacterized conserved protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. | Outer membrane porin; OprF. | 0.595 |
IL1984 | proA | IL1984 | IL1986 | Uncharacterized conserved protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. | 0.554 |
IL1984 | proB | IL1984 | IL1985 | Uncharacterized conserved protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | 0.554 |
birA | mutY | IL2003 | IL1983 | Biotin operon repressor/biotin--protein ligase fusion protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | A/G-specific DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.516 |
birA | trpC | IL2003 | IL1754 | Biotin operon repressor/biotin--protein ligase fusion protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Anthranilate isomerase; Belongs to the TrpC family. | 0.501 |
birA | xthA | IL2003 | IL1451 | Biotin operon repressor/biotin--protein ligase fusion protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Exonuclease III. | 0.873 |
dnaN | mutY | IL0002 | IL1983 | DNA polymerase sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...] | A/G-specific DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.541 |
dnaN | xthA | IL0002 | IL1451 | DNA polymerase sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...] | Exonuclease III. | 0.787 |
msrB | mutY | IL1525 | IL1983 | Two domain methionine sulfoxide reductase (MsrA/SelR); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | A/G-specific DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.486 |
mutY | IL1984 | IL1983 | IL1984 | A/G-specific DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Uncharacterized conserved protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. | 0.864 |
mutY | birA | IL1983 | IL2003 | A/G-specific DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Biotin operon repressor/biotin--protein ligase fusion protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.516 |
mutY | dnaN | IL1983 | IL0002 | A/G-specific DNA glycosylase; Adenine glycosylase active on G-A mispairs. | DNA polymerase sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...] | 0.541 |
mutY | msrB | IL1983 | IL1525 | A/G-specific DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Two domain methionine sulfoxide reductase (MsrA/SelR); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.486 |
mutY | oprF | IL1983 | IL1982 | A/G-specific DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Outer membrane porin; OprF. | 0.587 |
mutY | proA | IL1983 | IL1986 | A/G-specific DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. | 0.612 |
mutY | proB | IL1983 | IL1985 | A/G-specific DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | 0.593 |
mutY | sfsA | IL1983 | IL2249 | A/G-specific DNA glycosylase; Adenine glycosylase active on G-A mispairs. | SfsA; DNA-binding protein; stimulates sugar fermentation; Belongs to the SfsA family. | 0.919 |
mutY | trpC | IL1983 | IL1754 | A/G-specific DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Anthranilate isomerase; Belongs to the TrpC family. | 0.539 |
mutY | xthA | IL1983 | IL1451 | A/G-specific DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Exonuclease III. | 0.791 |