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tgt protein (Idiomarina loihiensis) - STRING interaction network
"tgt" - tRNA-guanine transglycosylase in Idiomarina loihiensis
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Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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tgttRNA-guanine transglycosylase; Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (373 aa)    
Predicted Functional Partners:
queA
S-adenosylmethionine-tRNA-ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (351 aa)
 
  0.999
queF
7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (274 aa)
       
  0.985
thyA
Thymidylate synthase; Provides the sole de novo source of dTMP for DNA biosynthesis (283 aa)
 
 
   
  0.744
pnp
Polynucleotide phosphorylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3’- to 5’-direction (716 aa)
 
   
  0.664
IL0328
Fused sugar kinase/hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (506 aa)
         
  0.629
trmD
tRNA-(guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs (252 aa)
   
   
  0.628
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP (525 aa)
   
   
  0.602
queE
Organic radical activating protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds (233 aa)
       
  0.593
rpoS
DNA-directed RNA polymerase sigma 38 subunit (322 aa)
   
 
  0.574
truB
tRNA pseudouridine 5S synthase; Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (310 aa)
   
   
  0.570
Your Current Organism:
Idiomarina loihiensis
NCBI taxonomy Id: 283942
Other names: I. loihiensis, I. loihiensis L2TR, Idiomarina loihiensis, Idiomarina loihiensis Donachie et al. 2003, Idiomarina loihiensis L2TR, Idiomarina loihiensis str. L2TR, Idiomarina loihiensis strain L2TR
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