STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIL1Nucleotide exchange factor SIL1; Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 (By similarity). (490 aa)    
Predicted Functional Partners:
KLLA0_F12210g
KLLA0F12210p.
   
 
 0.989
KLLA0_C16115g
KLLA0C16115p.
   
 
 0.989
KLLA0_F26455g
KLLA0F26455p.
   
 0.961
GRP78
Endoplasmic reticulum chaperone BiP; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis; Belongs to the heat shock protein 70 family.
   
 
 0.951
RPL25
60S ribosomal protein L25; Belongs to the universal ribosomal protein uL23 family.
  
 0.916
KLLA0_D06941g
KLLA0D06941p.
  
 0.915
KLLA0_A04587g
Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
  
 0.899
KLLA0_B05742g
KLLA0B05742p.
  
 0.899
KLLA0_F01793g
KLLA0F01793p; Belongs to the bacterial ribosomal protein bL17 family.
  
 0.898
KLLA0_F05247g
KLLA0F05247p.
  
 0.897
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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