node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERG1 | ERG11 | O13306 | P50859 | Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). | 0.996 |
ERG1 | ERG3 | O13306 | P50860 | Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. | Delta(7)-sterol 5(6)-desaturase; Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis. | 0.965 |
ERG1 | Q6FMX4_CANGA | O13306 | Q6FMX4 | Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. | Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. | 0.998 |
ERG1 | Q6FR73_CANGA | O13306 | Q6FR73 | Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. | 0.744 |
ERG1 | SCS7 | O13306 | Q6FUH7 | Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. | Ceramide very long chain fatty acid hydroxylase; Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2. | 0.718 |
ERG1 | SUR2 | O13306 | Q6FSD6 | Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. | Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. | 0.473 |
ERG11 | ERG1 | P50859 | O13306 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). | Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. | 0.996 |
ERG11 | ERG3 | P50859 | P50860 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). | Delta(7)-sterol 5(6)-desaturase; Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis. | 0.982 |
ERG11 | Q6FMX4_CANGA | P50859 | Q6FMX4 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). | Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. | 0.999 |
ERG11 | Q6FR73_CANGA | P50859 | Q6FR73 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. | 0.783 |
ERG11 | SCS7 | P50859 | Q6FUH7 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). | Ceramide very long chain fatty acid hydroxylase; Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2. | 0.708 |
ERG3 | ERG1 | P50860 | O13306 | Delta(7)-sterol 5(6)-desaturase; Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis. | Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. | 0.965 |
ERG3 | ERG11 | P50860 | P50859 | Delta(7)-sterol 5(6)-desaturase; Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis. | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). | 0.982 |
ERG3 | Q6FMX4_CANGA | P50860 | Q6FMX4 | Delta(7)-sterol 5(6)-desaturase; Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis. | Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. | 0.999 |
ERG3 | Q6FR73_CANGA | P50860 | Q6FR73 | Delta(7)-sterol 5(6)-desaturase; Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis. | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. | 0.760 |
ERG3 | SCS7 | P50860 | Q6FUH7 | Delta(7)-sterol 5(6)-desaturase; Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis. | Ceramide very long chain fatty acid hydroxylase; Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2. | 0.856 |
F2Z679_CANGA | Q6FR73_CANGA | F2Z679 | Q6FR73 | Succinate-semialdehyde dehydrogenase. | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. | 0.659 |
F2Z679_CANGA | SCS7 | F2Z679 | Q6FUH7 | Succinate-semialdehyde dehydrogenase. | Ceramide very long chain fatty acid hydroxylase; Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2. | 0.689 |
Q6FLC1_CANGA | Q6FMR1_CANGA | Q6FLC1 | Q6FMR1 | DAGKc domain-containing protein. | DAGKc domain-containing protein. | 0.903 |
Q6FLC1_CANGA | Q6FR73_CANGA | Q6FLC1 | Q6FR73 | DAGKc domain-containing protein. | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. | 0.488 |