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PAN2 protein (Candida glabrata) - STRING interaction network
"PAN2" - Hypothetical protein in Candida glabrata
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Predicted Interactions
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textmining
co-expression
protein homology
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PAN2Hypothetical protein; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome- mediated 3’-5’ exonucleolytic degradation, or deadenlyation- dependent mRNA decaping and subsequent 5’-3’ exonucleolytic degradation by XRN1. [...] (1093 aa)    
Predicted Functional Partners:
PAN3
Hypothetical protein; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome- mediated 3’-5’ exonucleolytic degradation, or deadenlyation- dependent mRNA decaping and subsequent 5’-3’ exonucleolytic degradation by XRN1 [...] (717 aa)
     
  0.998
XP_445490.1
Hypothetical protein; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (258 aa)
     
  0.902
PAB1
Hypothetical protein; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through trans [...] (579 aa)
       
  0.741
ARO1
Hypothetical protein; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis (1579 aa)
   
   
  0.706
CCR4
Hypothetical protein; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3’-5’ RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity) (873 aa)
     
 
  0.698
XP_447596.1
Ribosome biogenesis protein BRX1 (294 aa)
     
        0.681
XP_446689.1
Hypothetical protein (203 aa)
     
      0.656
XP_446017.1
Hypothetical protein (359 aa)
     
 
  0.644
XP_447890.1
Hypothetical protein (403 aa)
   
   
  0.635
YTM1
Hypothetical protein; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome (457 aa)
     
        0.627
Your Current Organism:
Candida glabrata
NCBI taxonomy Id: 284593
Other names: C. glabrata, C. glabrata CBS 138, Candida glabrata, Candida glabrata ATCC 2001, Candida glabrata ATCC2001, Candida glabrata CBS 138, Candida glabrata CBS138, Nakaseomyces, Torulopsis glabrata, m. Nakaseomyces, mitosporic Nakaseomyces
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