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PRP28 protein (Candida glabrata) - STRING interaction network
"PRP28" - Hypothetical protein in Candida glabrata
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PRP28Hypothetical protein; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5’-splice site duplex to permit an effective competition for the 5’-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5’-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity) (582 aa)    
Predicted Functional Partners:
XP_447350.1
Hypothetical protein (2414 aa)
     
  0.978
SMD2
Hypothetical protein (110 aa)
     
  0.969
LSM6
Hypothetical protein; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5’-to-3’ mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosoma [...] (115 aa)
     
  0.964
XP_002999599.1
Hypothetical protein (85 aa)
       
  0.951
XP_002999529.1
Hypothetical protein (76 aa)
       
    0.949
CLF1
Hypothetical protein; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity) (695 aa)
     
  0.946
XP_446788.1
Hypothetical protein (500 aa)
     
  0.926
XP_449287.1
Hypothetical protein (2140 aa)
     
  0.901
XP_446387.1
Hypothetical protein (1956 aa)
     
  0.893
XP_445285.1
Hypothetical protein (165 aa)
     
  0.884
Your Current Organism:
Candida glabrata
NCBI taxonomy Id: 284593
Other names: C. glabrata, C. glabrata CBS 138, Candida glabrata, Candida glabrata ATCC 2001, Candida glabrata ATCC2001, Candida glabrata CBS 138, Candida glabrata CBS138, Nakaseomyces, Torulopsis glabrata, m. Nakaseomyces, mitosporic Nakaseomyces
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