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CIS1 protein (Candida glabrata) - STRING interaction network
"CIS1" - Hypothetical protein in Candida glabrata
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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CIS1Hypothetical protein; Plays a role in starvation-induced autophagy. Involved in mitophagy. Functions with ATG17 and ATG29 at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. May be involved in microtubule function, such as chromosome segregation and karyogamy (By similarity) (182 aa)    
Predicted Functional Partners:
ATG29
Hypothetical protein; Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Plays also a role in mitophagy and regulation of filamentous growth (By similarity) (217 aa)
       
 
  0.953
ATG17
Hypothetical protein; Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity) (409 aa)
       
 
  0.952
ATG11
Hypothetical protein; Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity). Contributes through its regulation of pexophagy to survival during engulfment by host phagocytic cells during infection. Through its function in autophagy, acts as an important virulence factor t [...] (1110 aa)
       
 
  0.655
ATG1
Hypothetical protein; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS prod [...] (942 aa)
       
 
  0.634
ATG13
Hypothetical protein; Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity) (660 aa)
       
 
  0.601
XP_449229.1
Hypothetical protein (513 aa)
       
 
  0.467
VIK1
Hypothetical protein (584 aa)
       
 
  0.467
ATG12
Hypothetical protein; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity) (181 aa)
       
 
  0.466
ATG2
Hypothetical protein; Required for cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes completion and peroxisome degradation (1587 aa)
       
 
  0.466
ATG9
Hypothetical protein; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum- specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are [...] (928 aa)
           
  0.459
Your Current Organism:
Candida glabrata
NCBI taxonomy Id: 284593
Other names: C. glabrata, C. glabrata CBS 138, Candida glabrata, Candida glabrata ATCC 2001, Candida glabrata ATCC2001, Candida glabrata CBS 138, Candida glabrata CBS138, Nakaseomyces, Torulopsis glabrata, m. Nakaseomyces, mitosporic Nakaseomyces
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