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PAN3 protein (Candida glabrata) - STRING interaction network
"PAN3" - Hypothetical protein in Candida glabrata
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Predicted Interactions
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textmining
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protein homology
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PAN3Hypothetical protein; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome- mediated 3’-5’ exonucleolytic degradation, or deadenlyation- dependent mRNA decaping and subsequent 5’-3’ exonucleolytic degradation by XRN1 [...] (717 aa)    
Predicted Functional Partners:
PAN2
Hypothetical protein; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome- mediated 3’-5’ exonucleolytic degradation, or deadenlyation- dependent mRNA decaping and subsequent 5’-3’ exonucleolytic degradation by XRN1. [...] (1093 aa)
     
  0.998
REX3
Hypothetical protein; 3’ to 5’ exoribonuclease required for proper 3’ end maturation of MRP RNA and of the U5L snRNA (398 aa)
     
  0.904
REX4
Hypothetical protein; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity) (263 aa)
     
  0.904
XP_446381.1
Hypothetical protein (660 aa)
     
  0.904
PAB1
Hypothetical protein; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through trans [...] (579 aa)
       
  0.813
XP_447635.1
Hypothetical protein (602 aa)
       
  0.609
TIF45
Hypothetical protein; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (209 aa)
       
  0.549
TIF1
Hypothetical protein; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity) (396 aa)
         
  0.529
FAL1
Hypothetical protein; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity) (399 aa)
         
  0.527
CCR4
Hypothetical protein; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3’-5’ RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity) (873 aa)
     
 
  0.502
Your Current Organism:
Candida glabrata
NCBI taxonomy Id: 284593
Other names: C. glabrata, C. glabrata CBS 138, Candida glabrata, Candida glabrata ATCC 2001, Candida glabrata ATCC2001, Candida glabrata CBS 138, Candida glabrata CBS138, Nakaseomyces, Torulopsis glabrata, m. Nakaseomyces, mitosporic Nakaseomyces
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