STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dfg10Uncharacterized protein C7D4.09c. (274 aa)    
Predicted Functional Partners:
sec59
Dolichol kinase sec59; Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. It is required for spore germination. Has an essential role in cellular metabolism (By similarity). Belongs to the polyprenol kinase family.
     
 0.962
alg6
Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity); Belongs to the ALG6/ALG8 glucosyltransferase family.
      
 0.899
SPBP4H10.17c
Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity); Belongs to the AB hydrolase superfamily.
      
 0.732
chs1
Chitin synthase 1; Plays a major role in cell wall biogenesis.
      
 0.609
rer2
Dehydrodolichyl diphosphate synthase complex subunit SPAC4D7.04c; With nus1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).
   
  
 0.579
nus1
Dehydrodolichyl diphosphate synthase complex subunit nus1; With SPAC4D7.04c, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).
      
 0.579
tsc13
Putative enoyl reductase C646.07c; Belongs to the steroid 5-alpha reductase family.
    
 
 0.557
pdf1
Palmitoyl-protein thioesterase-dolichyl pyrophosphate phosphatase fusion 1; Essential protein. Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during vacuolar degradation. Required for efficient N- glycosylation. Necessary for maintaining optimal levels of dolichol- linked oligosaccharides; In the N-terminal section; belongs to the palmitoyl-protein thioesterase family.
      
 0.533
chs2
Chitin synthase-like protein 2; Plays a role in septum formation. Has no chitin synthase activity; Belongs to the chitin synthase family.
      
 0.531
gpt2
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; Catalyzes the initial step in the synthesis of dolichol-P-P- oligosaccharides; Belongs to the glycosyltransferase 4 family.
      
 0.478
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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