STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cox18Cytochrome c oxidase assembly protein cox18, mitochondrial; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the cox2 protein into the mitochondrial intermembrane space. Belongs to the OXA1/ALB3/YidC family. (202 aa)    
Predicted Functional Partners:
cox2
Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]
   
 
 0.978
mba1
Uncharacterized protein C13G7.11.
   
 
 0.788
trp2
Tryptophan synthase; In the C-terminal section; belongs to the TrpB family.
   
  
 0.712
sec6102
Uncharacterized protein C19G7.17.
   
 0.677
sec61
Protein transport protein sec61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to sec62/63 complex, secretory precursor polypeptides may engage sec61 to begin membrane penetration event. A cycle of assembly and disassembly of sec62/63 from sec61 may govern the activity of the translocase (By similarity).
   
 0.677
cox1102
Cytochrome c oxidase assembly protein cox11-2; Rsm22-2 is involved in mitochondrion-encoded protein synthesis; In the C-terminal section; belongs to the COX11/CtaG family.
   
  
 0.670
cox1101
Cytochrome c oxidase assembly protein cox11-1; Rsm22-1 is involved in mitochondrion-encoded protein synthesis; In the C-terminal section; belongs to the COX11/CtaG family.
   
  
 0.667
cox17
Cytochrome c oxidase copper chaperone; Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX (By similarity). Belongs to the COX17 family.
      
 0.661
oma1
Mitochondrial metalloendopeptidase OMA1; Protease that is part of the quality control system in the inner membrane of mitochondria. Cleaves and thereby promotes the turnover of mistranslated or misfolded membrane proteins (By similarity).
      
 0.621
etp1
Electron transfer protein 1, mitochondrial.
   
  
 0.597
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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