Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SPBP8B7.17c | SPBP8B7.18c | O94265 | O94266 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | 0.911 |
| SPBP8B7.17c | SPCC18B5.05c | O94265 | Q9USL6 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Belongs to the ThiD family. | 0.935 |
| SPBP8B7.17c | nmt1 | O94265 | P36597 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase; Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. | 0.917 |
| SPBP8B7.17c | pho4 | O94265 | Q01682 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | Thiamine-repressible acid phosphatase pho4; May dephosphorylate thiamine phosphates; Belongs to the histidine acid phosphatase family. | 0.961 |
| SPBP8B7.17c | thi2 | O94265 | P40998 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance. | 0.571 |
| SPBP8B7.17c | thi4 | O94265 | P40386 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | Probable thiamine biosynthetic bifunctional enzyme; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). In the C-terminal section; belongs to the Thz kinase family. | 0.989 |
| SPBP8B7.17c | tnr3 | O94265 | P41888 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | Thiamine pyrophosphokinase; Involved in the regulation of thiamine metabolism, phosphate metabolism, mating and cell growth. | 0.880 |
| SPBP8B7.18c | SPBP8B7.17c | O94266 | O94265 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | 0.911 |
| SPBP8B7.18c | SPCC18B5.05c | O94266 | Q9USL6 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Belongs to the ThiD family. | 0.918 |
| SPBP8B7.18c | nmt1 | O94266 | P36597 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase; Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. | 0.924 |
| SPBP8B7.18c | pho4 | O94266 | Q01682 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | Thiamine-repressible acid phosphatase pho4; May dephosphorylate thiamine phosphates; Belongs to the histidine acid phosphatase family. | 0.912 |
| SPBP8B7.18c | thi2 | O94266 | P40998 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance. | 0.635 |
| SPBP8B7.18c | thi4 | O94266 | P40386 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | Probable thiamine biosynthetic bifunctional enzyme; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). In the C-terminal section; belongs to the Thz kinase family. | 0.996 |
| SPBP8B7.18c | tnr3 | O94266 | P41888 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | Thiamine pyrophosphokinase; Involved in the regulation of thiamine metabolism, phosphate metabolism, mating and cell growth. | 0.542 |
| SPCC18B5.05c | SPBP8B7.17c | Q9USL6 | O94265 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Belongs to the ThiD family. | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | 0.935 |
| SPCC18B5.05c | SPBP8B7.18c | Q9USL6 | O94266 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Belongs to the ThiD family. | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family. | 0.918 |
| SPCC18B5.05c | nmt1 | Q9USL6 | P36597 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Belongs to the ThiD family. | 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase; Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. | 0.922 |
| SPCC18B5.05c | pho4 | Q9USL6 | Q01682 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Belongs to the ThiD family. | Thiamine-repressible acid phosphatase pho4; May dephosphorylate thiamine phosphates; Belongs to the histidine acid phosphatase family. | 0.905 |
| SPCC18B5.05c | thi2 | Q9USL6 | P40998 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Belongs to the ThiD family. | Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance. | 0.615 |
| SPCC18B5.05c | thi4 | Q9USL6 | P40386 | Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Belongs to the ThiD family. | Probable thiamine biosynthetic bifunctional enzyme; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). In the C-terminal section; belongs to the Thz kinase family. | 0.996 |
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