STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pka1cAMP-dependent protein kinase catalytic subunit. (512 aa)    
Predicted Functional Partners:
cgs1
cAMP-dependent protein kinase regulatory subunit.
 
 
 0.999
cyr1
Adenylate cyclase; Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.
   
 0.997
ras1
Ras-like protein 1; Participates in the process of sexual differentiation and the determination of cell shape. Essential for mating and for recognition of the mating pheromone, but not for vegetative growth. Does not regulate the intracellular cAMP level. Regulates two downstream pathways, namely the byr2/byr1/spk1 mitogen-activated protein kinase cascade and the cdc42 small G protein pathway. The former is relevant to mating and sporulation, whereas the latter is relevant to mating, cell growth and cell morphology.
   
 0.985
pmk1
Mitogen-activated protein kinase spm1; Regulates cell integrity and functions coordinately with the protein kinase C pathway (pck1 and pck2). Involved the regulation of wall architecture, cell shape, cytokinesis in exponential and stationary phase, and metabolism of ions.
  
0.939
ppk18
Serine/threonine-protein kinase ppk18.
  
0.936
cek1
Serine/threonine-protein kinase cek1; May facilitate the progression of anaphase through direct or indirect interaction with the cut8 protein.
  
0.935
git3
Glucose receptor protein git3; Activates gpa2 when triggered by glucose and then activates adenylate cyclase; Belongs to the G-protein coupled receptor GPR1/git3 family.
   
 
 0.889
git5
Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Required for adenylate cyclase activation.
 
 
  
 0.882
nte1
Lysophospholipase NTE1; Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity); Belongs to the NTE family.
   
 
 0.881
gpa2
Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. This protein may be involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of adenylyl cyclase; Belongs to the G-alpha family.
   
 
 0.874
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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