STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AQPAquaporin; Water channel required to facilitate the transport of water across membranes. Involved in osmotolerance. (250 aa)    
Predicted Functional Partners:
GPDH_ENCCU
Probable glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
  
  
 0.965
RPT6
26S proteasome regulatory subunit 8 homolog; Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity); Belongs to the AAA ATPase family.
  
 0.901
RPT2
26S proteasome regulatory subunit 4 homolog; Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity); Belongs to the AAA ATPase family.
  
 0.901
Q8SS82_ENCCU
26S PROTEASOME REGULATORY SUBUNIT 7; Belongs to the AAA ATPase family.
  
 0.901
Q8SWI0_ENCCU
Similarity to GLYCEROPHOSPHORYLDIESTER PHOSPHODIESTERASE.
  
 
 0.828
NDK1
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
  
 
 0.804
Q8SQZ1_ENCCU
Triosephosphate isomerase.
     
 0.792
Q8SQU0_ENCCU
HSP 101 RELATED PROTEIN.
     
 0.787
Q8SSJ6_ENCCU
GUANYLATE KINASE.
      
 0.787
Q8SSH2_ENCCU
CLATHRIN COAT ASSEMBLY PROTEIN; Belongs to the adaptor complexes medium subunit family.
    
 
 0.756
Your Current Organism:
Encephalitozoon cuniculi
NCBI taxonomy Id: 284813
Other names: E. cuniculi GB-M1, Encephalitozoon cuniculi GB-M1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.