node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDR_ENCCU | DHFR-1 | Q8SSK6 | O62583 | Aldose reductase; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.925 |
DHFR-1 | ALDR_ENCCU | O62583 | Q8SSK6 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Aldose reductase; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. | 0.925 |
DHFR-1 | DUT1 | O62583 | Q8SRS0 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.634 |
DHFR-1 | Q8SS22_ENCCU | O62583 | Q8SS22 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | THYMIDYLATE KINASE. | 0.963 |
DHFR-1 | Q8SS63_ENCCU | O62583 | Q8SS63 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.817 |
DHFR-1 | Q8SSK4_ENCCU | O62583 | Q8SSK4 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | CDP-DIACYLGLYCEROLINOSITOL-3-PHOSPHATIDYLTRANSFERASE; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.648 |
DHFR-1 | Q8SVU7_ENCCU | O62583 | Q8SVU7 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Glucosamine_iso domain-containing protein. | 0.659 |
DHFR-1 | SHMT-1 | O62583 | O62585 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.995 |
DHFR-1 | TK | O62583 | O96720 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Thymidine kinase. | 0.946 |
DHFR-1 | TS-1 | O62583 | O62584 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Thymidylate synthase 1/2; Belongs to the thymidylate synthase family. | 0.997 |
DHFR-1 | TS-3 | O62583 | Q8SRG2 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Thymidylate synthase 3; Belongs to the thymidylate synthase family. | 0.997 |
DUT1 | DHFR-1 | Q8SRS0 | O62583 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.634 |
DUT1 | Q8SS22_ENCCU | Q8SRS0 | Q8SS22 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | THYMIDYLATE KINASE. | 0.958 |
DUT1 | SHMT-1 | Q8SRS0 | O62585 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.401 |
DUT1 | TK | Q8SRS0 | O96720 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidine kinase. | 0.967 |
DUT1 | TS-1 | Q8SRS0 | O62584 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase 1/2; Belongs to the thymidylate synthase family. | 0.972 |
DUT1 | TS-3 | Q8SRS0 | Q8SRG2 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase 3; Belongs to the thymidylate synthase family. | 0.972 |
Q8SS22_ENCCU | DHFR-1 | Q8SS22 | O62583 | THYMIDYLATE KINASE. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.963 |
Q8SS22_ENCCU | DUT1 | Q8SS22 | Q8SRS0 | THYMIDYLATE KINASE. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.958 |
Q8SS22_ENCCU | Q8SS63_ENCCU | Q8SS22 | Q8SS63 | THYMIDYLATE KINASE. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.615 |