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FEN1 protein (Phaeodactylum tricornutum) - STRING interaction network
"FEN1" - Flap endonuclease 1 in Phaeodactylum tricornutum
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
FEN1Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] (421 aa)    
Predicted Functional Partners:
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (260 aa)
     
  0.989
Phatr19604
Predicted protein (363 aa)
   
  0.962
Phatr51005
DNA ligase (651 aa)
 
  0.951
MRE11
Predicted protein (550 aa)
   
  0.936
RFC4
Predicted protein (350 aa)
   
  0.910
Phatr10585
Predicted protein (337 aa)
 
  0.883
RFC3
Predicted protein (361 aa)
   
  0.871
Mlh1
Mutl-like protein 1 (695 aa)
   
  0.868
Phatr27246
Predicted protein (283 aa)
   
  0.868
Phatr9529
Predicted protein (348 aa)
   
  0.862
Your Current Organism:
Phaeodactylum tricornutum
NCBI taxonomy Id: 2850
Other names: Bacillariophyceae, Bacillariophycidae, Naviculales, P. tricornutum, Phaeodactylaceae, Phaeodactylum, Phaeodactylum tricornutum, Raphid, pennate diatoms
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