STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SeMB42_g06213Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (933 aa)    
Predicted Functional Partners:
SeMB42_g03445
Kinase; Belongs to the inositol phosphokinase (IPK) family.
    
 0.888
IPK1
Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
     
 0.830
SeMB42_g00445
Kinase; Belongs to the inositol phosphokinase (IPK) family.
    
 0.758
SeMB42_g03342
FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]
    
   0.574
SeMB42_g01497
SPX domain-containing protein.
    
 
 0.573
SeMB42_g05959
GP-PDE domain-containing protein.
    
 
 0.546
SeMB42_g04044
Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family.
    
   0.539
SeMB42_g05431
PUA domain-containing protein.
    
 
 0.506
SeMB42_g04474
HECT domain-containing protein.
      
 0.506
SeMB42_g03663
Uncharacterized protein.
    
   0.459
Your Current Organism:
Synchytrium endobioticum
NCBI taxonomy Id: 286115
Other names: S. endobioticum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.