STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FumACatalyzes the reversible hydration of fumarate to (S)-malate. (507 aa)    
Predicted Functional Partners:
sdhC
succ_dehyd_cytB: succinate dehydrogenase, cytochrome b556 subunit
  
 
 0.997
fumC
Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
  
 
 0.995
fumC2
Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
  
 
 0.995
sdhA
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily
  
 
 0.990
sdhD
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
 
 0.986
MaeB
annotation not available
 
 
 0.981
acnB
Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Catalyzes the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnB functions as a RNA-binding regulatory protein
 
  
 0.977
maeA
Belongs to the malic enzymes family
  
 
 0.975
gltA
cit_synth_I: citrate (Si)-synthase; Belongs to the citrate synthase family
  
 
 0.972
sdhB
dhsB: succinate dehydrogenase and fumarate reductase iron-sulfur family protein
  
 
 0.968
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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