STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DR97_1552Acrb/acrd/acrf family protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family (1018 aa)    
Predicted Functional Partners:
DR97_1551
Membrane fusion protein, multidrug efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
 0.991
DR97_5828
Membrane fusion protein, multidrug efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
 0.957
OmpH
type_I_sec_TolC: type I secretion outer membrane , TolC family protein
 
 0.955
mexA
Membrane fusion protein, multidrug efflux system; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine
 0.952
oprM
Major intrinsic multiple antibiotic resistance efflux outer membrane protein; The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the [...]
 
 0.898
AmrB
2A0602: RND transporter, hydrophobe/amphiphile efflux-1 family protein
  
 
 
0.829
mexB
Multidrug resistance protein mexb; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine
  
  
 
0.818
mexC
Membrane fusion protein, multidrug efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
 0.788
DR97_5643
Membrane fusion protein, multidrug efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
 0.773
DR97_588
Putative rnd efflux membrane fusion protein precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
 0.770
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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