STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
fumC2Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate (458 aa)    
Predicted Functional Partners:
FumA
Catalyzes the reversible hydration of fumarate to (S)-malate.
  
 
 0.995
sodA
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems
  
 
 0.990
sucA
2oxo_dh_E1: oxoglutarate dehydrogenase (succinyl-transferring), E1 component
  
 
 0.982
sdhC
succ_dehyd_cytB: succinate dehydrogenase, cytochrome b556 subunit
   
 
 0.980
sdhA
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily
  
 0.976
gltA
cit_synth_I: citrate (Si)-synthase; Belongs to the citrate synthase family
   
 0.974
sucD
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. Can also generate UTP or CTP, although it preferentially synthesizes ATP and/or GTP
  
 0.960
sdhB
dhsB: succinate dehydrogenase and fumarate reductase iron-sulfur family protein
  
 0.960
DR97_1650
annotation not available
  
  
 0.958
mqo1
Probable malate:quinone oxidoreductase; Mal_quin_oxido: malate dehydrogenase
  
 
 0.947
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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