| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DR97_1678 | Metallopeptidase | DR97_1678 | DR97_1677 | annotation not available | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | 0.570 |
| DR97_2734 | Metallopeptidase | DR97_2734 | DR97_1677 | Hypothetical protein; Glycyl-glycine endopeptidase LytM | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | 0.858 |
| DR97_2734 | lasA | DR97_2734 | DR97_4 | Hypothetical protein; Glycyl-glycine endopeptidase LytM | Lasa protease precursor; Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly- Gly-|-X substrates where X is Ala or Gly . Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases . Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in [...] | 0.681 |
| DR97_6213 | DR97_668 | DR97_6213 | DR97_668 | annotation not available | 4-hydroxyproline epimerase; Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting trans-4-hydroxy- L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp), which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell mitogen. Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways. Cannot use L- proline, trans-3-hydroxy-L-proline (t3LHyp) and pyrrolidone-5- carboxylate (P5C) as substrate | 0.779 |
| DR97_6213 | Metallopeptidase | DR97_6213 | DR97_1677 | annotation not available | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | 0.495 |
| DR97_668 | DR97_6213 | DR97_668 | DR97_6213 | 4-hydroxyproline epimerase; Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting trans-4-hydroxy- L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp), which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell mitogen. Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways. Cannot use L- proline, trans-3-hydroxy-L-proline (t3LHyp) and pyrrolidone-5- carboxylate (P5C) as substrate | annotation not available | 0.779 |
| DR97_668 | DR97_684 | DR97_668 | DR97_684 | 4-hydroxyproline epimerase; Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting trans-4-hydroxy- L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp), which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell mitogen. Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways. Cannot use L- proline, trans-3-hydroxy-L-proline (t3LHyp) and pyrrolidone-5- carboxylate (P5C) as substrate | annotation not available | 0.965 |
| DR97_668 | Metallopeptidase | DR97_668 | DR97_1677 | 4-hydroxyproline epimerase; Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting trans-4-hydroxy- L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp), which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell mitogen. Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways. Cannot use L- proline, trans-3-hydroxy-L-proline (t3LHyp) and pyrrolidone-5- carboxylate (P5C) as substrate | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | 0.487 |
| DR97_684 | DR97_668 | DR97_684 | DR97_668 | annotation not available | 4-hydroxyproline epimerase; Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting trans-4-hydroxy- L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp), which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell mitogen. Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways. Cannot use L- proline, trans-3-hydroxy-L-proline (t3LHyp) and pyrrolidone-5- carboxylate (P5C) as substrate | 0.965 |
| DR97_684 | Metallopeptidase | DR97_684 | DR97_1677 | annotation not available | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | 0.485 |
| Metallopeptidase | DR97_1678 | DR97_1677 | DR97_1678 | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | annotation not available | 0.570 |
| Metallopeptidase | DR97_2734 | DR97_1677 | DR97_2734 | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | Hypothetical protein; Glycyl-glycine endopeptidase LytM | 0.858 |
| Metallopeptidase | DR97_6213 | DR97_1677 | DR97_6213 | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | annotation not available | 0.495 |
| Metallopeptidase | DR97_668 | DR97_1677 | DR97_668 | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | 4-hydroxyproline epimerase; Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting trans-4-hydroxy- L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp), which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell mitogen. Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways. Cannot use L- proline, trans-3-hydroxy-L-proline (t3LHyp) and pyrrolidone-5- carboxylate (P5C) as substrate | 0.487 |
| Metallopeptidase | DR97_684 | DR97_1677 | DR97_684 | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | annotation not available | 0.485 |
| Metallopeptidase | gltB | DR97_1677 | DR97_2391 | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | annotation not available | 0.545 |
| Metallopeptidase | lasA | DR97_1677 | DR97_4 | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | Lasa protease precursor; Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly- Gly-|-X substrates where X is Ala or Gly . Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases . Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in [...] | 0.681 |
| Metallopeptidase | opdP | DR97_1677 | DR97_1680 | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | annotation not available | 0.443 |
| Metallopeptidase | pepA | DR97_1677 | DR97_4035 | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity) | 0.546 |
| Metallopeptidase | phnW | DR97_1677 | DR97_484 | Metallopeptidase m24 family protein; Belongs to the peptidase M24B family | 2-aminoethylphosphonate-pyruvate transaminase; Involved in phosphonate degradation | 0.431 |
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