Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
uvrD/REP helicase N-terminal domain protein (493 aa)
Predicted Functional Partners:
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (913 aa)
annotation not available (441 aa)
Hypothetical bacteriophage protein (229 aa)
Pilus assembly protein PilV; Bacterial shufflon , N-terminal constant region family protein (459 aa)
annotation not available (374 aa)
Uncharacterized protein (233 aa)
recQ- ATP-dependent DNA helicase RecQ (712 aa)
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (633 aa)
TraG/TraD family protein; conj_TOL_TraD- conjugative coupling factor TraD, PFGI-1 class (743 aa)