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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pilY1Neisseria pilc beta-propeller domain protein; Involved in pilus assembly, twitching motility and adhesion to host cells. Primes type IV pili (T4P) assembly and is required for inclusion of minor pilins PilV, PilW and PilX to the surface pili . Stabilizes assembled pilus fibers likely by antagonizing retraction mediated by PilT. Calcium-binding and calcium release by PilY1 seem to be essential for twitching motility and for regulation of pilus retraction dynamics of PilT (By similarity) (1163 aa)    
Predicted Functional Partners:
pilW
Type iv pilus assembly protein pilw; Type 4 fimbrial biogenesis protein PilW; IV_pilin_GFxxxE: prepilin-type N-terminal cleavage/methylation domain protein
 
  
 0.998
pilE
Type iv pilus assembly protein pile; Type 4 fimbrial biogenesis protein PilE; IV_pilin_GFxxxE: prepilin-type N-terminal cleavage/methylation domain protein
 
  
 0.998
pilV
Type 4 fimbrial biogenesis protein; type_IV_pilV: type IV pilus modification protein PilV
 
  
 0.996
fimU
annotation not available
 
  
 0.994
pilX
Type iv pilus assembly protein pilx; Type 4 fimbrial biogenesis protein PilX; pilX N-terminal family protein
 
  
 0.993
pilY2
annotation not available
  
  
 0.985
fimT
Hypothetical protein; Type 4 fimbrial biogenesis protein FimT; IV_pilin_GFxxxE: prepilin-type N-terminal cleavage/methylation domain protein
 
   
 0.969
pilU
pilT_fam: twitching motility family protein
 
  
 0.909
pilT
Twitching motility protein pilt; May be involved in pilus retraction
 
  
 0.907
PilC
annotation not available
 
  
 0.905
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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