acrR protein (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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textmining

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protein homology

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[Homology]

Score

acrR

annotation not available (186 aa)

Predicted Functional Partners:

ramA

0.864

marR

0.857

acrA

0.854

acrB

0.853

acrD

0.760

entH

0.755

DR97_6160

0.754

DR97_2182

0.754

soxR_2

0.750

gyrA

0.723

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DR97_2182	acrR	DR97_2182	DR97_2181	annotation not available	annotation not available	0.754
DR97_2182	entH	DR97_2182	DR97_2180	annotation not available	Proofreading thioesterase EntH	0.515
DR97_6160	acrR	DR97_6160	DR97_2181	soxR- redox-sensitive transcriptional activator SoxR	annotation not available	0.754
DR97_6160	marR	DR97_6160	DR97_2524	soxR- redox-sensitive transcriptional activator SoxR	annotation not available	0.870
DR97_6160	ramA	DR97_6160	DR97_4341	soxR- redox-sensitive transcriptional activator SoxR	annotation not available	0.550
acrA	acrB	DR97_1905	DR97_1904	Acriflavine resistance protein A; RND_mfp- efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein	0.997
acrA	acrD	DR97_1905	DR97_5829	Acriflavine resistance protein A; RND_mfp- efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein	0.984
acrA	acrR	DR97_1905	DR97_2181	Acriflavine resistance protein A; RND_mfp- efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	annotation not available	0.854
acrA	gyrA	DR97_1905	DR97_4768	Acriflavine resistance protein A; RND_mfp- efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	0.590
acrA	marR	DR97_1905	DR97_2524	Acriflavine resistance protein A; RND_mfp- efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	annotation not available	0.589
acrA	ramA	DR97_1905	DR97_4341	Acriflavine resistance protein A; RND_mfp- efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	annotation not available	0.765
acrB	acrA	DR97_1904	DR97_1905	2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein	Acriflavine resistance protein A; RND_mfp- efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	0.997
acrB	acrR	DR97_1904	DR97_2181	2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein	annotation not available	0.853
acrB	gyrA	DR97_1904	DR97_4768	2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein	DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	0.508
acrB	marR	DR97_1904	DR97_2524	2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein	annotation not available	0.623
acrB	ramA	DR97_1904	DR97_4341	2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein	annotation not available	0.750
acrD	acrA	DR97_5829	DR97_1905	2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein	Acriflavine resistance protein A; RND_mfp- efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	0.984
acrD	acrR	DR97_5829	DR97_2181	2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein	annotation not available	0.760
acrD	marR	DR97_5829	DR97_2524	2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein	annotation not available	0.554
acrD	ramA	DR97_5829	DR97_4341	2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein	annotation not available	0.459

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