cntM protein (Pseudomonas aeruginosa) - STRING interaction network

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cntM

Staphylopine/pseudopaline/yersinopine synthase; Catalyzes the NAD(P)H-dependent reductive condensation of alpha-ketoglutarate to the intermediate formed by the adjacently encoded enzyme PA4836, namely (2S)-2-amino-4- pseudopaline. This is the last step in the biosynthesis of the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to Pseudomonas virulence. Can use neither pyruvate nor oxaloacetate in place of alpha-ketoglutarate Is [...] (433 aa)

Predicted Functional Partners:

cntL

0.986

cntI

0.949

cntO

0.871

DR97_2188

0.558

DR97_5924

0.548

DR97_6022

0.545

DR97_2183

0.535

amiA

0.533

hasR

0.520

DR97_6021

0.517

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DR97_2183	DR97_5924	DR97_2183	DR97_5924	Hemolysin-III related; hlyIII: channel , hemolysin III family protein	annotation not available	0.510
DR97_2183	DR97_6021	DR97_2183	DR97_6021	Hemolysin-III related; hlyIII: channel , hemolysin III family protein	annotation not available	0.532
DR97_2183	amiA	DR97_2183	DR97_2916	Hemolysin-III related; hlyIII: channel , hemolysin III family protein	annotation not available	0.419
DR97_2183	cntI	DR97_2183	DR97_2184	Hemolysin-III related; hlyIII: channel , hemolysin III family protein	Eama-like transporter family protein; Transports the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Is probably involved in the export of pseudopaline (By similarity). Essential for iron acquisition during the interaction with airway mucus secretions (AMS)	0.526
DR97_2183	cntL	DR97_2183	DR97_2186	Hemolysin-III related; hlyIII: channel , hemolysin III family protein	Histidine 2-aminobutanoyltransferase; Catalyzes the nucleophilic attack of one alpha-aminobutanoate moiety from SAM onto L-histidine to produce the intermediate (2S)-2- amino-4- Functions in the biosynthesis of the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to Pseudomonas virulence. Appears to be specific for L-histidine as substrate	0.495
DR97_2183	cntM	DR97_2183	DR97_2185	Hemolysin-III related; hlyIII: channel , hemolysin III family protein	Staphylopine/pseudopaline/yersinopine synthase; Catalyzes the NAD(P)H-dependent reductive condensation of alpha-ketoglutarate to the intermediate formed by the adjacently encoded enzyme PA4836, namely (2S)-2-amino-4- pseudopaline. This is the last step in the biosynthesis of the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to Pseudomonas virulence. Can use neither pyruvate nor oxaloacetate in place of alpha-ketoglutarate Is [...]	0.535
DR97_2183	hasR	DR97_2183	DR97_4513	Hemolysin-III related; hlyIII: channel , hemolysin III family protein	annotation not available	0.518
DR97_2188	cntI	DR97_2188	DR97_2184	annotation not available	Eama-like transporter family protein; Transports the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Is probably involved in the export of pseudopaline (By similarity). Essential for iron acquisition during the interaction with airway mucus secretions (AMS)	0.628
DR97_2188	cntL	DR97_2188	DR97_2186	annotation not available	Histidine 2-aminobutanoyltransferase; Catalyzes the nucleophilic attack of one alpha-aminobutanoate moiety from SAM onto L-histidine to produce the intermediate (2S)-2- amino-4- Functions in the biosynthesis of the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to Pseudomonas virulence. Appears to be specific for L-histidine as substrate	0.592
DR97_2188	cntM	DR97_2188	DR97_2185	annotation not available	Staphylopine/pseudopaline/yersinopine synthase; Catalyzes the NAD(P)H-dependent reductive condensation of alpha-ketoglutarate to the intermediate formed by the adjacently encoded enzyme PA4836, namely (2S)-2-amino-4- pseudopaline. This is the last step in the biosynthesis of the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to Pseudomonas virulence. Can use neither pyruvate nor oxaloacetate in place of alpha-ketoglutarate Is [...]	0.558
DR97_2188	cntO	DR97_2188	DR97_2187	annotation not available	Tonb-dependent siderophore receptor family protein; Transports the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Is probably involved in the import of pseudopaline-metal complexes	0.765
DR97_5924	DR97_2183	DR97_5924	DR97_2183	annotation not available	Hemolysin-III related; hlyIII: channel , hemolysin III family protein	0.510
DR97_5924	DR97_6021	DR97_5924	DR97_6021	annotation not available	annotation not available	0.446
DR97_5924	DR97_6022	DR97_5924	DR97_6022	annotation not available	annotation not available	0.417
DR97_5924	amiA	DR97_5924	DR97_2916	annotation not available	annotation not available	0.637
DR97_5924	cntI	DR97_5924	DR97_2184	annotation not available	Eama-like transporter family protein; Transports the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Is probably involved in the export of pseudopaline (By similarity). Essential for iron acquisition during the interaction with airway mucus secretions (AMS)	0.580
DR97_5924	cntL	DR97_5924	DR97_2186	annotation not available	Histidine 2-aminobutanoyltransferase; Catalyzes the nucleophilic attack of one alpha-aminobutanoate moiety from SAM onto L-histidine to produce the intermediate (2S)-2- amino-4- Functions in the biosynthesis of the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to Pseudomonas virulence. Appears to be specific for L-histidine as substrate	0.613
DR97_5924	cntM	DR97_5924	DR97_2185	annotation not available	Staphylopine/pseudopaline/yersinopine synthase; Catalyzes the NAD(P)H-dependent reductive condensation of alpha-ketoglutarate to the intermediate formed by the adjacently encoded enzyme PA4836, namely (2S)-2-amino-4- pseudopaline. This is the last step in the biosynthesis of the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to Pseudomonas virulence. Can use neither pyruvate nor oxaloacetate in place of alpha-ketoglutarate Is [...]	0.548
DR97_5924	cntO	DR97_5924	DR97_2187	annotation not available	Tonb-dependent siderophore receptor family protein; Transports the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Is probably involved in the import of pseudopaline-metal complexes	0.579
DR97_5924	hasR	DR97_5924	DR97_4513	annotation not available	annotation not available	0.440

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