node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DR97_2318 | parC | DR97_2318 | DR97_2317 | Putative aspartyl protease; clan_AA_DTGA: clan AA aspartic protease, TIGR02281 family protein | Dna topoisomerase iv, a subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule | 0.920 |
DR97_2318 | parE | DR97_2318 | DR97_2320 | Putative aspartyl protease; clan_AA_DTGA: clan AA aspartic protease, TIGR02281 family protein | Dna topoisomerase iv, b subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule | 0.806 |
NfxB | ampC | DR97_1902 | DR97_3761 | annotation not available | Beta-lactamase class c pdc; Belongs to the class-C beta-lactamase family | 0.671 |
NfxB | gyrA | DR97_1902 | DR97_4768 | annotation not available | Dna gyrase, a subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | 0.860 |
NfxB | gyrB | DR97_1902 | DR97_2953 | annotation not available | Dna gyrase, b subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | 0.494 |
NfxB | mexR | DR97_1902 | DR97_3392 | annotation not available | Marr family transcriptional regulator, repressor of the mexab-oprm multidrug resistance operon; Repressor of the mexAB-oprM multidrug resistance operon. Also represses its own expression. Many variants lead to increased expression of the mexAB-oprM operon | 0.855 |
NfxB | oprJ | DR97_1902 | DR97_1903 | annotation not available | Outer membrane protein, multidrug efflux system; Channel-forming component of a multidrug resistance efflux pump | 0.857 |
NfxB | parC | DR97_1902 | DR97_2317 | annotation not available | Dna topoisomerase iv, a subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule | 0.859 |
NfxB | parE | DR97_1902 | DR97_2320 | annotation not available | Dna topoisomerase iv, b subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule | 0.491 |
ampC | NfxB | DR97_3761 | DR97_1902 | Beta-lactamase class c pdc; Belongs to the class-C beta-lactamase family | annotation not available | 0.671 |
ampC | gyrA | DR97_3761 | DR97_4768 | Beta-lactamase class c pdc; Belongs to the class-C beta-lactamase family | Dna gyrase, a subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | 0.889 |
ampC | gyrB | DR97_3761 | DR97_2953 | Beta-lactamase class c pdc; Belongs to the class-C beta-lactamase family | Dna gyrase, b subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | 0.759 |
ampC | mexR | DR97_3761 | DR97_3392 | Beta-lactamase class c pdc; Belongs to the class-C beta-lactamase family | Marr family transcriptional regulator, repressor of the mexab-oprm multidrug resistance operon; Repressor of the mexAB-oprM multidrug resistance operon. Also represses its own expression. Many variants lead to increased expression of the mexAB-oprM operon | 0.611 |
ampC | nfxB | DR97_3761 | DR97_1906 | Beta-lactamase class c pdc; Belongs to the class-C beta-lactamase family | Tetr/acrr family transcriptional regulator, mexcd-oprj operon repressor; Confers resistance to guinolones. May negatively regulate the expression of genes that are associated with cell permeability to drugs | 0.671 |
ampC | oprJ | DR97_3761 | DR97_1903 | Beta-lactamase class c pdc; Belongs to the class-C beta-lactamase family | Outer membrane protein, multidrug efflux system; Channel-forming component of a multidrug resistance efflux pump | 0.854 |
ampC | parC | DR97_3761 | DR97_2317 | Beta-lactamase class c pdc; Belongs to the class-C beta-lactamase family | Dna topoisomerase iv, a subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule | 0.875 |
ampC | parE | DR97_3761 | DR97_2320 | Beta-lactamase class c pdc; Belongs to the class-C beta-lactamase family | Dna topoisomerase iv, b subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule | 0.761 |
gyrA | NfxB | DR97_4768 | DR97_1902 | Dna gyrase, a subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | annotation not available | 0.860 |
gyrA | ampC | DR97_4768 | DR97_3761 | Dna gyrase, a subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | Beta-lactamase class c pdc; Belongs to the class-C beta-lactamase family | 0.889 |
gyrA | gyrB | DR97_4768 | DR97_2953 | Dna gyrase, a subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | Dna gyrase, b subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | 0.999 |