STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppk1Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (714 aa)    
Predicted Functional Partners:
ppk2
Uses inorganic polyphosphate (polyP) as a donor to convert ADP to ATP and GDP to GTP. Can also catalyze the synthesis of polyP from ATP or GTP, but the rate of polyP utilization is 75-fold greater than the rate of polyP synthesis
 
  
 0.981
DR97_6005
Uses inorganic polyphosphate (polyP) as a donor to convert ADP to ATP
 
  
 0.980
ppx
Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain . Has also polyphosphate:ADP phosphotransferase activity, catalyzing the production of ATP from ADP and polyP
 
  
 0.977
ppa
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
    
 0.972
DR97_5504
Uncharacterized protein; PPK2_P_aer: polyphosphate kinase 2
 
   
 0.913
lon
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
      
 0.875
Lon
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
      
 0.874
DR97_1429
annotation not available
     
 0.872
phoA2
Has both a phosphomonoesterase and phosphodiesterase activity
     
 0.872
pstS
Binds 1 inorganic phosphate per subunit with a KD of 0.34 uM . Required for phosphate transport . In strain PAO1 implicated in host cell adhesion; in some virulent strains (e.g. MDR25 which expresses very high levels of this protein) antibody fragments against this protein decrease host cell adhesion and increase transepithelial resistance of human epithelial cell monolayers. Its ability to bind phosphate may allow it to acquire phosphate from its host
     
 0.872
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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