Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| algC | algR | DR97_2693 | DR97_2632 | Phosphomannomutase / phosphoglucomutase; Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity . Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enz [...] | Two-component system, lyttr family, response regulator algr; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway | 0.864 |
| algC | algU | DR97_2693 | DR97_1221 | Phosphomannomutase / phosphoglucomutase; Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity . Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enz [...] | Rna polymerase sigma-70 factor, ecf subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates genes such as algD, involved in alginate biosynthesis | 0.863 |
| algC | amrZ | DR97_2693 | DR97_4537 | Phosphomannomutase / phosphoglucomutase; Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity . Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enz [...] | Arc-like dna binding domain protein; Functions as both a transcriptional activator and repressor of multiple genes encoding virulence factors as well as genes involved in environmental adaptation Plays a role in alginate production via the activation of AlgD which is the first gene in the alginate biosynthetic operon . Regulates also the transcription of genes responsible for type IV pili localization and twitching motility . Mediates transition of P.aeruginosa biofilm infections from colonizing to chronic biofilms through repression of the psl operon . Represses also its own transcrip [...] | 0.683 |
| algC | kinB | DR97_2693 | DR97_2862 | Phosphomannomutase / phosphoglucomutase; Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity . Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enz [...] | annotation not available | 0.579 |
| algC | mucB | DR97_2693 | DR97_1219 | Phosphomannomutase / phosphoglucomutase; Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity . Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enz [...] | Sigma-e factor negative regulatory protein rseb; Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate-producing form. Inactivation of mucB causes conversion to mucoidy | 0.671 |
| algQ | algR | DR97_2626 | DR97_2632 | Regulator of rna polymerase sigma(70) subunit, rsd/algq family protein; The promoter for a critical alginate biosynthetic gene, AlgD, encoding GDP-mannose dehydrogenase, is activated only under conditions reminiscent of the cystic fibrosis lung (i.e. under high osmolarity), and at least two regulatory genes, AlgP and AlgQ, have been implicated in this activation process | Two-component system, lyttr family, response regulator algr; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway | 0.873 |
| algQ | algU | DR97_2626 | DR97_1221 | Regulator of rna polymerase sigma(70) subunit, rsd/algq family protein; The promoter for a critical alginate biosynthetic gene, AlgD, encoding GDP-mannose dehydrogenase, is activated only under conditions reminiscent of the cystic fibrosis lung (i.e. under high osmolarity), and at least two regulatory genes, AlgP and AlgQ, have been implicated in this activation process | Rna polymerase sigma-70 factor, ecf subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates genes such as algD, involved in alginate biosynthesis | 0.715 |
| algQ | hemD | DR97_2626 | DR97_2630 | Regulator of rna polymerase sigma(70) subunit, rsd/algq family protein; The promoter for a critical alginate biosynthetic gene, AlgD, encoding GDP-mannose dehydrogenase, is activated only under conditions reminiscent of the cystic fibrosis lung (i.e. under high osmolarity), and at least two regulatory genes, AlgP and AlgQ, have been implicated in this activation process | Uroporphyrinogen-iii synthase hemd family protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III | 0.431 |
| algQ | kinB | DR97_2626 | DR97_2862 | Regulator of rna polymerase sigma(70) subunit, rsd/algq family protein; The promoter for a critical alginate biosynthetic gene, AlgD, encoding GDP-mannose dehydrogenase, is activated only under conditions reminiscent of the cystic fibrosis lung (i.e. under high osmolarity), and at least two regulatory genes, AlgP and AlgQ, have been implicated in this activation process | annotation not available | 0.408 |
| algQ | mucB | DR97_2626 | DR97_1219 | Regulator of rna polymerase sigma(70) subunit, rsd/algq family protein; The promoter for a critical alginate biosynthetic gene, AlgD, encoding GDP-mannose dehydrogenase, is activated only under conditions reminiscent of the cystic fibrosis lung (i.e. under high osmolarity), and at least two regulatory genes, AlgP and AlgQ, have been implicated in this activation process | Sigma-e factor negative regulatory protein rseb; Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate-producing form. Inactivation of mucB causes conversion to mucoidy | 0.627 |
| algR | algC | DR97_2632 | DR97_2693 | Two-component system, lyttr family, response regulator algr; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway | Phosphomannomutase / phosphoglucomutase; Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity . Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enz [...] | 0.864 |
| algR | algQ | DR97_2632 | DR97_2626 | Two-component system, lyttr family, response regulator algr; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway | Regulator of rna polymerase sigma(70) subunit, rsd/algq family protein; The promoter for a critical alginate biosynthetic gene, AlgD, encoding GDP-mannose dehydrogenase, is activated only under conditions reminiscent of the cystic fibrosis lung (i.e. under high osmolarity), and at least two regulatory genes, AlgP and AlgQ, have been implicated in this activation process | 0.873 |
| algR | algU | DR97_2632 | DR97_1221 | Two-component system, lyttr family, response regulator algr; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway | Rna polymerase sigma-70 factor, ecf subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates genes such as algD, involved in alginate biosynthesis | 0.883 |
| algR | algZ | DR97_2632 | DR97_2633 | Two-component system, lyttr family, response regulator algr; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway | annotation not available | 0.995 |
| algR | amrZ | DR97_2632 | DR97_4537 | Two-component system, lyttr family, response regulator algr; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway | Arc-like dna binding domain protein; Functions as both a transcriptional activator and repressor of multiple genes encoding virulence factors as well as genes involved in environmental adaptation Plays a role in alginate production via the activation of AlgD which is the first gene in the alginate biosynthetic operon . Regulates also the transcription of genes responsible for type IV pili localization and twitching motility . Mediates transition of P.aeruginosa biofilm infections from colonizing to chronic biofilms through repression of the psl operon . Represses also its own transcrip [...] | 0.864 |
| algR | hemC | DR97_2632 | DR97_2631 | Two-component system, lyttr family, response regulator algr; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps | 0.878 |
| algR | hemD | DR97_2632 | DR97_2630 | Two-component system, lyttr family, response regulator algr; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway | Uroporphyrinogen-iii synthase hemd family protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III | 0.862 |
| algR | kinB | DR97_2632 | DR97_2862 | Two-component system, lyttr family, response regulator algr; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway | annotation not available | 0.910 |
| algR | mucB | DR97_2632 | DR97_1219 | Two-component system, lyttr family, response regulator algr; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway | Sigma-e factor negative regulatory protein rseb; Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate-producing form. Inactivation of mucB causes conversion to mucoidy | 0.869 |
| algR | vfr | DR97_2632 | DR97_3605 | Two-component system, lyttr family, response regulator algr; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway | Crp/fnr family transcriptional regulator, cyclic amp receptor protein; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production | 0.888 |
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