STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
norMMultidrug resistance protein, mate family; Multidrug efflux pump (488 aa)    
Predicted Functional Partners:
ispH
4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis
     
 0.873
DR97_2664
Lysr family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family
       0.705
DR97_829
annotation not available
     
 0.700
AmrB
2A0602: RND transporter, hydrophobe/amphiphile efflux-1 family protein
  
  
 0.679
macB
Macrolide transport system atp-binding/permease protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides
  
  
 0.673
DR97_4644
Rna polymerase sigma-70 factor, ecf subfamily; Belongs to the sigma-70 factor family. ECF subfamily
      
 0.623
WaaL
O-antigen ligase family protein; Potential O-antigen polymerase, which may be involved in the synthesis of LPS
      
 0.528
YrbE
Phospholipid/cholesterol/gamma-hch transport system permease protein; Putative phospholipid ABC transporter permease protein MlaE
     
 0.521
DR97_1551
Membrane fusion protein, multidrug efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
   
  
 0.519
DR97_5446
Membrane fusion protein; RND_mfp: efflux transporter, RND family, MFP subunit
   
  
 0.519
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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