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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdhCHypothetical protein; 3-keto-5-aminohexanoate cleavage enzyme (294 aa)    
Predicted Functional Partners:
lcdH
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein; Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3- dehydrocarnitine. Is specific for L-carnitine and NAD(+) as substrates. D,L-3-hydroxybutyrate, L-lactate, ethanol, L-malate and D,L-isocitrate are not substrates. Is involved in a L-carnitine degradation pathway that allows P.aeruginosa to grow on L-carnitine as the sole source of carbon and nitrogen
 
  
 0.995
cdhB
Acyl-coa thioester hydrolase; 4-hydroxybenzoyl-CoA thioesterase
 
    0.950
cdhR
Helix-turn-helix domain protein; Induces the transcription of the PA5384-PA5388 operon in response to carnitine. This operon is involved in the degradation of L- carnitine, and allows P.aeruginosa to grow on L-carnitine as the sole source of carbon and nitrogen
 
   
 0.950
betI
Tetr/acrr family transcriptional regulator, transcriptional repressor of bet genes; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity)
      
 0.847
DR97_2764
Glycine betaine/proline transport system substrate-binding protein; ABC_choline_bnd: choline ABC transporter, periplasmic binding family protein
 
    0.744
CatD
Uncharacterized protein; protocat_pcaD: 3-oxoadipate enol-lactonase
     
 0.692
pcaD
Beta-ketoadipate enol-lactone hydrolase; protocat_pcaD: 3-oxoadipate enol-lactonase
     
 0.691
betB
Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid
      
 0.684
gbdR
annotation not available
 
   
 0.671
DR97_2759
annotation not available
  
    0.649
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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