STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
tse6Paar motif family protein; Type VI secretion exported toxin that acts as a glycohydrolase on bacterial target cells and degrades the essential dinucleotides NAD(+) and NADP(+), thereby inducing bacteriostasis. The activity resides in the C-terminal region that is initially neutralized by the cognate immunity protein Tsi6 (430 aa)    
Predicted Functional Partners:
tsi6
Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse5
  
   0.977
eagT6
Hypothetical protein; Plays an essential role in toxin Tse6 delivery to target cells and specifically in the loading of Tse6 onto VgrG1a
 
  
 0.965
vgrG1a
Rhs element vgr family protein; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 1/Hcp1 . Allows the delivery of the Tse6 toxin to target cells where it exerts its toxicity
 
  
 0.902
DR97_3058
Hypothetical protein; Uncharacterized protein
 
    0.828
DR97_3055
3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl synthase, N-terminal domain protein
 
  
 0.818
DR97_3054
Hypothetical protein; Uncharacterized protein
 
  
 0.801
tufA
Translation elongation factor tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis
    
   0.800
DR97_3646
annotation not available
    
   0.800
DR97_3053
Hypothetical protein; Uncharacterized protein
 
  
 0.789
tse7
Ghh signature containing hnh/endo vii supernuclease toxin 2 family protein; Type VI secretion exported toxin that via to its DNase activity induces growth arrest and ultimately DNA degradation within target cell . The activity is initially neutralized by a cognate immunity protein Tsi7
 
     0.765
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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