node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DR97_2545 | Hpt | DR97_2545 | DR97_1954 | Hydrolase; HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein | annotation not available | 0.900 |
DR97_2545 | guaA | DR97_2545 | DR97_4101 | Hydrolase; HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | 0.919 |
DR97_2545 | guaB | DR97_2545 | DR97_4100 | Hydrolase; HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.910 |
DR97_2545 | rdgB | DR97_2545 | DR97_3354 | Hydrolase; HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein | Non-canonical purine ntp pyrophosphatase, rdgb/ham1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions | 0.902 |
DR97_2545 | surE | DR97_2545 | DR97_4314 | Hydrolase; HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein | Stationary phase survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates | 0.806 |
DR97_2545 | xpt | DR97_2545 | DR97_2669 | Hydrolase; HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis | 0.902 |
DR97_3355 | rdgB | DR97_3355 | DR97_3354 | Conserved hypothetical protein | Non-canonical purine ntp pyrophosphatase, rdgb/ham1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions | 0.894 |
Hpt | DR97_2545 | DR97_1954 | DR97_2545 | annotation not available | Hydrolase; HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein | 0.900 |
Hpt | guaA | DR97_1954 | DR97_4101 | annotation not available | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | 0.985 |
Hpt | guaB | DR97_1954 | DR97_4100 | annotation not available | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.978 |
Hpt | rdgB | DR97_1954 | DR97_3354 | annotation not available | Non-canonical purine ntp pyrophosphatase, rdgb/ham1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions | 0.907 |
Hpt | surE | DR97_1954 | DR97_4314 | annotation not available | Stationary phase survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates | 0.900 |
Hpt | xpt | DR97_1954 | DR97_2669 | annotation not available | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis | 0.880 |
guaA | DR97_2545 | DR97_4101 | DR97_2545 | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | Hydrolase; HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein | 0.919 |
guaA | Hpt | DR97_4101 | DR97_1954 | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | annotation not available | 0.985 |
guaA | guaB | DR97_4101 | DR97_4100 | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.999 |
guaA | ndk | DR97_4101 | DR97_4062 | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. The 12-kDa membrane-associated form synthesizes GTP in preference to other nucleoside triphosphates. Important for alginate synthesis | 0.648 |
guaA | rdgB | DR97_4101 | DR97_3354 | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | Non-canonical purine ntp pyrophosphatase, rdgb/ham1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions | 0.967 |
guaA | rph | DR97_4101 | DR97_2705 | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation | 0.452 |
guaA | surE | DR97_4101 | DR97_4314 | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | Stationary phase survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates | 0.942 |