| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DR97_2545 | guaA | DR97_2545 | DR97_4101 | Hydrolase; HAD-SF-IA-v3- HAD hydrolase, IA, variant 3 family protein | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | 0.918 |
| DR97_2545 | guaB | DR97_2545 | DR97_4100 | Hydrolase; HAD-SF-IA-v3- HAD hydrolase, IA, variant 3 family protein | Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family | 0.910 |
| DR97_2545 | hpt | DR97_2545 | DR97_1954 | Hydrolase; HAD-SF-IA-v3- HAD hydrolase, IA, variant 3 family protein | annotation not available | 0.900 |
| DR97_2545 | rdgB | DR97_2545 | DR97_3354 | Hydrolase; HAD-SF-IA-v3- HAD hydrolase, IA, variant 3 family protein | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | 0.904 |
| DR97_2545 | surE | DR97_2545 | DR97_4314 | Hydrolase; HAD-SF-IA-v3- HAD hydrolase, IA, variant 3 family protein | 5’-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5’-monophosphates; Belongs to the SurE nucleotidase family | 0.804 |
| DR97_2545 | xpt | DR97_2545 | DR97_2669 | Hydrolase; HAD-SF-IA-v3- HAD hydrolase, IA, variant 3 family protein | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5’-monophosphate (XMP), so it can be reused for RNA or DNA synthesis | 0.902 |
| DR97_3355 | rdgB | DR97_3355 | DR97_3354 | Conserved hypothetical protein | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | 0.894 |
| cca | rdgB | DR97_3552 | DR97_3354 | Multifunctional CCA protein; Catalyzes the addition and repair of the essential 3’- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2’- nucleotidase and 2’,3’-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3’-CCA terminus degraded by intracellular RNases | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | 0.883 |
| guaA | DR97_2545 | DR97_4101 | DR97_2545 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | Hydrolase; HAD-SF-IA-v3- HAD hydrolase, IA, variant 3 family protein | 0.918 |
| guaA | guaB | DR97_4101 | DR97_4100 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family | 0.999 |
| guaA | hpt | DR97_4101 | DR97_1954 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | annotation not available | 0.982 |
| guaA | ndk | DR97_4101 | DR97_4062 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate | 0.639 |
| guaA | rdgB | DR97_4101 | DR97_3354 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family | 0.973 |
| guaA | rph | DR97_4101 | DR97_2705 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | Ribonuclease PH; Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates | 0.593 |
| guaA | surE | DR97_4101 | DR97_4314 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | 5’-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5’-monophosphates; Belongs to the SurE nucleotidase family | 0.944 |
| guaA | xpt | DR97_4101 | DR97_2669 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5’-monophosphate (XMP), so it can be reused for RNA or DNA synthesis | 0.987 |
| guaB | DR97_2545 | DR97_4100 | DR97_2545 | Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family | Hydrolase; HAD-SF-IA-v3- HAD hydrolase, IA, variant 3 family protein | 0.910 |
| guaB | guaA | DR97_4100 | DR97_4101 | Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | 0.999 |
| guaB | hpt | DR97_4100 | DR97_1954 | Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family | annotation not available | 0.964 |
| guaB | ndk | DR97_4100 | DR97_4062 | Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate | 0.758 |
