metX protein (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

metX

Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine (379 aa)

Predicted Functional Partners:

metW

0.999

hom

0.990

cysD1

0.980

metZ

0.931

metH

0.929

DR97_3358

0.718

cysN/C

0.693

DR97_3355

0.679

rdgB

0.679

cysG

0.667

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DR97_3355	DR97_3358	DR97_3355	DR97_3358	Conserved hypothetical protein	annotation not available	0.537
DR97_3355	metW	DR97_3355	DR97_3356	Conserved hypothetical protein	metW- methionine biosynthesis protein MetW	0.923
DR97_3355	metX	DR97_3355	DR97_3357	Conserved hypothetical protein	Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	0.679
DR97_3355	rdgB	DR97_3355	DR97_3354	Conserved hypothetical protein	dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family	0.894
DR97_3358	DR97_3355	DR97_3358	DR97_3355	annotation not available	Conserved hypothetical protein	0.537
DR97_3358	metW	DR97_3358	DR97_3356	annotation not available	metW- methionine biosynthesis protein MetW	0.738
DR97_3358	metX	DR97_3358	DR97_3357	annotation not available	Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	0.718
DR97_3358	rdgB	DR97_3358	DR97_3354	annotation not available	dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family	0.558
cysD1	cysG	DR97_2380	DR97_5351	OAH_OAS_sulfhy- O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein	Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	0.512
cysD1	cysN/C	DR97_2380	DR97_1620	OAH_OAS_sulfhy- O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein	Multifunctional fusion protein; Catalyzes the synthesis of activated sulfate; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily	0.675
cysD1	hom	DR97_2380	DR97_4141	OAH_OAS_sulfhy- O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein	annotation not available	0.868
cysD1	metH	DR97_2380	DR97_34	OAH_OAS_sulfhy- O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein	metH- methionine synthase	0.988
cysD1	metW	DR97_2380	DR97_3356	OAH_OAS_sulfhy- O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein	metW- methionine biosynthesis protein MetW	0.887
cysD1	metX	DR97_2380	DR97_3357	OAH_OAS_sulfhy- O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein	Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	0.980
cysD1	metZ	DR97_2380	DR97_4826	OAH_OAS_sulfhy- O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein	O_suc_HS_sulf- O-succinylhomoserine sulfhydrylase	0.929
cysG	cysD1	DR97_5351	DR97_2380	Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	OAH_OAS_sulfhy- O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein	0.512
cysG	cysN/C	DR97_5351	DR97_1620	Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	Multifunctional fusion protein; Catalyzes the synthesis of activated sulfate; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily	0.958
cysG	metH	DR97_5351	DR97_34	Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	metH- methionine synthase	0.706
cysG	metX	DR97_5351	DR97_3357	Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	0.667
cysG	metZ	DR97_5351	DR97_4826	Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	O_suc_HS_sulf- O-succinylhomoserine sulfhydrylase	0.629

page 1 of 4

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2019

Credits

Access

Info

About