| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| folD | gcvT1 | DR97_90 | DR97_2584 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine | 0.973 |
| folD | gcvT3 | DR97_90 | DR97_5990 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate | Aminomethyltransferase, mitochondrial; gcvT- glycine cleavage system T protein | 0.974 |
| folD | glyA1 | DR97_90 | DR97_2792 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.989 |
| folD | glyA2 | DR97_90 | DR97_1908 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.990 |
| folD | glyA3 | DR97_90 | DR97_5988 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.991 |
| folD | metE | DR97_90 | DR97_5918 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate | met_syn_B12ind- 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase | 0.469 |
| folD | metF | DR97_90 | DR97_3398 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate | Fadh2- 5,10-methylenetetrahydrofolate reductase | 0.956 |
| folD | metH | DR97_90 | DR97_34 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate | metH- methionine synthase | 0.757 |
| folD | thyA | DR97_90 | DR97_3308 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate | Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis | 0.937 |
| gcvT1 | folD | DR97_2584 | DR97_90 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine | Bifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate | 0.973 |
| gcvT1 | gcvT3 | DR97_2584 | DR97_5990 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine | Aminomethyltransferase, mitochondrial; gcvT- glycine cleavage system T protein | 0.829 |
| gcvT1 | glyA1 | DR97_2584 | DR97_2792 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.989 |
| gcvT1 | glyA2 | DR97_2584 | DR97_1908 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.987 |
| gcvT1 | glyA3 | DR97_2584 | DR97_5988 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.984 |
| gcvT1 | metF | DR97_2584 | DR97_3398 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine | Fadh2- 5,10-methylenetetrahydrofolate reductase | 0.929 |
| gcvT1 | metH | DR97_2584 | DR97_34 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine | metH- methionine synthase | 0.935 |
| gcvT1 | thyA | DR97_2584 | DR97_3308 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine | Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis | 0.925 |
| gcvT3 | folD | DR97_5990 | DR97_90 | Aminomethyltransferase, mitochondrial; gcvT- glycine cleavage system T protein | Bifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate | 0.974 |
| gcvT3 | gcvT1 | DR97_5990 | DR97_2584 | Aminomethyltransferase, mitochondrial; gcvT- glycine cleavage system T protein | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine | 0.829 |
| gcvT3 | glyA1 | DR97_5990 | DR97_2792 | Aminomethyltransferase, mitochondrial; gcvT- glycine cleavage system T protein | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.988 |
