lipA protein (Pseudomonas aeruginosa) - STRING interaction network

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lipA

Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (327 aa)

Predicted Functional Partners:

lipB

0.999

pqqE

0.921

DR97_3869

0.891

fabI

0.854

fabF3

0.834

fabF1

0.831

DR97_3055

0.831

fabB

0.831

fabV

0.800

bioB

0.798

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DR97_3055	fabB	DR97_3055	DR97_280	Beta-ketoacyl synthase, N-terminal domain protein	3-oxoacyl-[acyl-carrier-protein] synthase 1; Thiolase, N-terminal domain protein; Belongs to the beta-ketoacyl-ACP synthases family	0.800
DR97_3055	fabF1	DR97_3055	DR97_4974	Beta-ketoacyl synthase, N-terminal domain protein	3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	0.900
DR97_3055	fabF3	DR97_3055	DR97_425	Beta-ketoacyl synthase, N-terminal domain protein	3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	0.900
DR97_3055	fabI	DR97_3055	DR97_73	Beta-ketoacyl synthase, N-terminal domain protein	annotation not available	0.931
DR97_3055	fabV	DR97_3055	DR97_4989	Beta-ketoacyl synthase, N-terminal domain protein	Enoyl-[acyl-carrier-protein] reductase [NADH]; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family	0.912
DR97_3055	lipA	DR97_3055	DR97_3871	Beta-ketoacyl synthase, N-terminal domain protein	Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	0.831
DR97_3055	lipB	DR97_3055	DR97_3870	Beta-ketoacyl synthase, N-terminal domain protein	Octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	0.817
DR97_3869	lipA	DR97_3869	DR97_3871	UPF0250 protein AO964_03820; Belongs to the UPF0250 family	Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	0.891
DR97_3869	lipB	DR97_3869	DR97_3870	UPF0250 protein AO964_03820; Belongs to the UPF0250 family	Octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	0.906
bioB	lipA	DR97_3468	DR97_3871	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family	Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	0.798
bioB	pqqE	DR97_3468	DR97_5858	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family	Pyrroloquinoline quinone biosynthesis protein; PQQ_syn_pqqE- coenzyme PQQ biosynthesis enzyme PqqE	0.610
fabB	DR97_3055	DR97_280	DR97_3055	3-oxoacyl-[acyl-carrier-protein] synthase 1; Thiolase, N-terminal domain protein; Belongs to the beta-ketoacyl-ACP synthases family	Beta-ketoacyl synthase, N-terminal domain protein	0.800
fabB	fabF1	DR97_280	DR97_4974	3-oxoacyl-[acyl-carrier-protein] synthase 1; Thiolase, N-terminal domain protein; Belongs to the beta-ketoacyl-ACP synthases family	3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	0.920
fabB	fabF3	DR97_280	DR97_425	3-oxoacyl-[acyl-carrier-protein] synthase 1; Thiolase, N-terminal domain protein; Belongs to the beta-ketoacyl-ACP synthases family	3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	0.926
fabB	fabI	DR97_280	DR97_73	3-oxoacyl-[acyl-carrier-protein] synthase 1; Thiolase, N-terminal domain protein; Belongs to the beta-ketoacyl-ACP synthases family	annotation not available	0.994
fabB	fabV	DR97_280	DR97_4989	3-oxoacyl-[acyl-carrier-protein] synthase 1; Thiolase, N-terminal domain protein; Belongs to the beta-ketoacyl-ACP synthases family	Enoyl-[acyl-carrier-protein] reductase [NADH]; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family	0.985
fabB	lipA	DR97_280	DR97_3871	3-oxoacyl-[acyl-carrier-protein] synthase 1; Thiolase, N-terminal domain protein; Belongs to the beta-ketoacyl-ACP synthases family	Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	0.831
fabB	lipB	DR97_280	DR97_3870	3-oxoacyl-[acyl-carrier-protein] synthase 1; Thiolase, N-terminal domain protein; Belongs to the beta-ketoacyl-ACP synthases family	Octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	0.822
fabF1	DR97_3055	DR97_4974	DR97_3055	3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	Beta-ketoacyl synthase, N-terminal domain protein	0.900
fabF1	fabB	DR97_4974	DR97_280	3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	3-oxoacyl-[acyl-carrier-protein] synthase 1; Thiolase, N-terminal domain protein; Belongs to the beta-ketoacyl-ACP synthases family	0.920

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