STRINGSTRING
apt protein (Pseudomonas aeruginosa) - STRING interaction network
"apt" - Adenine phosphoribosyltransferase in Pseudomonas aeruginosa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (182 aa)    
Predicted Functional Partners:
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP (525 aa)
   
  0.990
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family (215 aa)
   
 
  0.960
add
Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (316 aa)
   
  0.959
DR97_5333
purB- adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily (456 aa)
   
  0.956
DR97_4426
annotation not available (483 aa)
   
  0.944
DR97_4425
purB- adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily (477 aa)
   
  0.944
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP (203 aa)
   
 
  0.936
purH
Bifunctional purine biosynthesis protein PurH; purH- phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (535 aa)
   
 
  0.931
mazG
Nucleoside triphosphate pyrophosphohydrolase; mazG- MazG family protein (276 aa)
   
 
  0.920
nuh
annotation not available (350 aa)
       
  0.918
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
Server load: low (17%) [HD]