node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hpt | apt | DR97_1954 | DR97_393 | annotation not available | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | 0.909 |
Hpt | gmk | DR97_1954 | DR97_2707 | annotation not available | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP | 0.963 |
Hpt | guaA | DR97_1954 | DR97_4101 | annotation not available | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | 0.985 |
Hpt | guaB | DR97_1954 | DR97_4100 | annotation not available | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.978 |
Hpt | purA | DR97_1954 | DR97_2291 | annotation not available | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | 0.974 |
Hpt | purD | DR97_1954 | DR97_2206 | annotation not available | Phosphoribosylamine---glycine ligase; purD: phosphoribosylamine--glycine ligase; Belongs to the GARS family | 0.574 |
Hpt | purH | DR97_1954 | DR97_2205 | annotation not available | Bifunctional purine biosynthesis protein PurH; purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | 0.964 |
Hpt | purL | DR97_1954 | DR97_4112 | annotation not available | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.546 |
Hpt | xpt | DR97_1954 | DR97_2669 | annotation not available | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis | 0.880 |
apt | Hpt | DR97_393 | DR97_1954 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | annotation not available | 0.909 |
apt | gmk | DR97_393 | DR97_2707 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP | 0.937 |
apt | guaA | DR97_393 | DR97_4101 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | 0.988 |
apt | guaB | DR97_393 | DR97_4100 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.634 |
apt | purA | DR97_393 | DR97_2291 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | 0.599 |
apt | purD | DR97_393 | DR97_2206 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Phosphoribosylamine---glycine ligase; purD: phosphoribosylamine--glycine ligase; Belongs to the GARS family | 0.646 |
apt | purH | DR97_393 | DR97_2205 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Bifunctional purine biosynthesis protein PurH; purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | 0.968 |
apt | purL | DR97_393 | DR97_4112 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.718 |
apt | xpt | DR97_393 | DR97_2669 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis | 0.967 |
carB | gmk | DR97_2100 | DR97_2707 | CPSaseII_lrg: carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP | 0.601 |
carB | guaA | DR97_2100 | DR97_4101 | CPSaseII_lrg: carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | 0.973 |